FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108607004> ?p ?o ?g. }

• W2108607004 endingPage "140" @default.
• W2108607004 startingPage "135" @default.
• W2108607004 abstract "The mutagenicity of peroxyl radicals, important participants in lipid peroxidation cascades, was investigated using a plasmid-based mutational assay system. Double-stranded pSP189 plasmids were incubated with a range of concentrations of the water-soluble peroxyl radical generator 2,2'-azobis(2-amidinopropane) hydrochloride (AAPH). Following replication in human Ad293 cells, the plasmids were screened for supF mutations in indicator bacteria. Exposure to peroxyl radicals caused strand nicking and a decrease in transfection efficiency, which was accompanied by a significant increase in supF mutants. Each of these effects was abolished in the presence of the water-soluble vitamin E analogue Trolox. Automated sequencing of 76 AAPH-induced mutant plasmids revealed that substitutions at G:C base pairs were the most common changes, accounting for 85.5% of all identified mutations. Of these, most comprised G:C-->T:A transversions (53.5%), with lesser contributions by G:C-->A:T transitions (23.9%) and G:C-->C:G transversions (22.5%). Collectively, these data confirm our previous findings concerning the spectrum of mutations produced upon bacterial replication of peroxyl radical-damaged phage DNA and extend them by showing that such damage has mutagenic consequences during replication in more complex eukaryotic systems." @default.
• W2108607004 created "2016-06-24" @default.
• W2108607004 creator A5008406455 @default.
• W2108607004 creator A5064377615 @default.
• W2108607004 date "1999-01-01" @default.
• W2108607004 modified "2023-09-26" @default.
• W2108607004 title "Mutations at G:C base pairs predominate after replication of peroxyl radical-damaged pSP189 plasmids in human cells" @default.
• W2108607004 cites W1480907902 @default.
• W2108607004 cites W1510630022 @default.
• W2108607004 cites W1548245551 @default.
• W2108607004 cites W1845321470 @default.
• W2108607004 cites W1934175771 @default.
• W2108607004 cites W1965796676 @default.
• W2108607004 cites W1965892507 @default.
• W2108607004 cites W1966607943 @default.
• W2108607004 cites W1969149902 @default.
• W2108607004 cites W1974188968 @default.
• W2108607004 cites W1981873649 @default.
• W2108607004 cites W1983496733 @default.
• W2108607004 cites W1984367999 @default.
• W2108607004 cites W1999432535 @default.
• W2108607004 cites W2001041995 @default.
• W2108607004 cites W2004752551 @default.
• W2108607004 cites W2005741634 @default.
• W2108607004 cites W2013535221 @default.
• W2108607004 cites W2020450602 @default.
• W2108607004 cites W2023138117 @default.
• W2108607004 cites W2032833465 @default.
• W2108607004 cites W2036352133 @default.
• W2108607004 cites W2036994807 @default.
• W2108607004 cites W2055173460 @default.
• W2108607004 cites W2056593089 @default.
• W2108607004 cites W2057067964 @default.
• W2108607004 cites W2059613678 @default.
• W2108607004 cites W2064387695 @default.
• W2108607004 cites W2064891860 @default.
• W2108607004 cites W2068074879 @default.
• W2108607004 cites W2070213944 @default.
• W2108607004 cites W2075836341 @default.
• W2108607004 cites W2082216829 @default.
• W2108607004 cites W2086481868 @default.
• W2108607004 cites W2086764007 @default.
• W2108607004 cites W2092120060 @default.
• W2108607004 cites W2105311935 @default.
• W2108607004 cites W2111284995 @default.
• W2108607004 cites W2120464591 @default.
• W2108607004 cites W2136510623 @default.
• W2108607004 cites W2138934674 @default.
• W2108607004 cites W2140365442 @default.
• W2108607004 cites W2143295797 @default.
• W2108607004 cites W2143660140 @default.
• W2108607004 cites W2147062173 @default.
• W2108607004 cites W2151665882 @default.
• W2108607004 doi "https://doi.org/10.1093/mutage/14.1.135" @default.
• W2108607004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10474835" @default.
• W2108607004 hasPublicationYear "1999" @default.
• W2108607004 type Work @default.
• W2108607004 sameAs 2108607004 @default.
• W2108607004 citedByCount "13" @default.
• W2108607004 countsByYear W21086070042013 @default.
• W2108607004 countsByYear W21086070042014 @default.
• W2108607004 countsByYear W21086070042015 @default.
• W2108607004 crossrefType "journal-article" @default.
• W2108607004 hasAuthorship W2108607004A5008406455 @default.
• W2108607004 hasAuthorship W2108607004A5064377615 @default.
• W2108607004 hasBestOaLocation W21086070041 @default.
• W2108607004 hasConcept C104317684 @default.
• W2108607004 hasConcept C143065580 @default.
• W2108607004 hasConcept C153911025 @default.
• W2108607004 hasConcept C16318435 @default.
• W2108607004 hasConcept C185581394 @default.
• W2108607004 hasConcept C185592680 @default.
• W2108607004 hasConcept C22744801 @default.
• W2108607004 hasConcept C2776231299 @default.
• W2108607004 hasConcept C2778004101 @default.
• W2108607004 hasConcept C2781401929 @default.
• W2108607004 hasConcept C501734568 @default.
• W2108607004 hasConcept C54009773 @default.
• W2108607004 hasConcept C552990157 @default.
• W2108607004 hasConcept C55493867 @default.
• W2108607004 hasConcept C73573662 @default.
• W2108607004 hasConcept C86803240 @default.
• W2108607004 hasConceptScore W2108607004C104317684 @default.
• W2108607004 hasConceptScore W2108607004C143065580 @default.
• W2108607004 hasConceptScore W2108607004C153911025 @default.
• W2108607004 hasConceptScore W2108607004C16318435 @default.
• W2108607004 hasConceptScore W2108607004C185581394 @default.
• W2108607004 hasConceptScore W2108607004C185592680 @default.
• W2108607004 hasConceptScore W2108607004C22744801 @default.
• W2108607004 hasConceptScore W2108607004C2776231299 @default.
• W2108607004 hasConceptScore W2108607004C2778004101 @default.
• W2108607004 hasConceptScore W2108607004C2781401929 @default.
• W2108607004 hasConceptScore W2108607004C501734568 @default.
• W2108607004 hasConceptScore W2108607004C54009773 @default.
• W2108607004 hasConceptScore W2108607004C552990157 @default.
• W2108607004 hasConceptScore W2108607004C55493867 @default.
• W2108607004 hasConceptScore W2108607004C73573662 @default.
• W2108607004 hasConceptScore W2108607004C86803240 @default.

• next