FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108639775> ?p ?o ?g. }

• W2108639775 abstract "The main problem in schistosomal hepatic morbidity is fibrosis and extensive scarring induced by living eggs. In this study, we tried to study the effect of treatment using antihelminthic drug (PZQ) and/or antifibrotic drugs (PTX and silymarin) in combination with immunization. The parasitological parameters, the dynamics of serum-specific immunoglobulins and splenic cytokines associated with changes in granuloma diameter were assessed. Naive mice were immunized intravenously with 10 ug of SEA in three doses at 2 days intervals 6 weeks before infection. Animals were infected by tail immersion with 100 cercariae and divided into several groups. Three groups were treated with PZQ, PTX or silymarin administered alone. Another two groups were treated with PZQ combined with PTX or silymarin. All treated animals and respective controls were sacrificed 12 weeks post infection. Immunization did not affect worm reduction , but slight decrease in granuloma diameter, increase in immunoglobulins and cytokines was observed . Reduction in worm burden was associated with reduction in ova count and changes in oogram pattern which were mainly due to PZQ treatment. Increasing reduction in granuloma diameter, elevation of immunogloulins and cytokines levels were observed in the groups treated with PZQ alone or cmbined with PTX or silymarin. In conclusion, in this study, treatment with PZQ complemented with immunization resulted in significant reduction of parasitological parameters and rise of specific Igs. Addition of antifibrotic drugs PTX or silymarin to PZQ, potentiated an antipathology effect which minimized and ameliorated liver fibrosis by inhibition of HSC activation and accentuation of the effect of suppressor Treg cells. (Journal of American Science 2010; 6(5):208-216). (ISSN: 1545-1003). Key word: Schistosoma mansoni, Praziquantel, Pentoxifyllin, silymarin." @default.
• W2108639775 created "2016-06-24" @default.
• W2108639775 creator A5015297404 @default.
• W2108639775 creator A5025011346 @default.
• W2108639775 creator A5041147754 @default.
• W2108639775 creator A5059708249 @default.
• W2108639775 creator A5068012459 @default.
• W2108639775 creator A5075128025 @default.
• W2108639775 date "2010-07-01" @default.
• W2108639775 modified "2023-09-27" @default.
• W2108639775 title "OL-037 Effect of treatment with antifibrotic drugs in combination with PZQ in immunized Schistosoma mansoni infected murine model" @default.
• W2108639775 cites W1447118129 @default.
• W2108639775 cites W1488389671 @default.
• W2108639775 cites W1657280255 @default.
• W2108639775 cites W1663232976 @default.
• W2108639775 cites W1964082152 @default.
• W2108639775 cites W1989888749 @default.
• W2108639775 cites W2005454919 @default.
• W2108639775 cites W2006300406 @default.
• W2108639775 cites W2007141982 @default.
• W2108639775 cites W2010274889 @default.
• W2108639775 cites W2011561507 @default.
• W2108639775 cites W2014463662 @default.
• W2108639775 cites W2021118536 @default.
• W2108639775 cites W2022996048 @default.
• W2108639775 cites W2027537159 @default.
• W2108639775 cites W2032067219 @default.
• W2108639775 cites W2036536337 @default.
• W2108639775 cites W2065584304 @default.
• W2108639775 cites W2065902165 @default.
• W2108639775 cites W2079084729 @default.
• W2108639775 cites W2081660202 @default.
• W2108639775 cites W2082866365 @default.
• W2108639775 cites W2084855813 @default.
• W2108639775 cites W2092314228 @default.
• W2108639775 cites W2115016225 @default.
• W2108639775 cites W2119656609 @default.
• W2108639775 cites W2128635872 @default.
• W2108639775 cites W2130870680 @default.
• W2108639775 cites W2133330937 @default.
• W2108639775 cites W2133975863 @default.
• W2108639775 cites W21359101 @default.
• W2108639775 cites W2137128482 @default.
• W2108639775 cites W2158129157 @default.
• W2108639775 cites W2158723210 @default.
• W2108639775 cites W2169776110 @default.
• W2108639775 cites W2320310176 @default.
• W2108639775 cites W2331104599 @default.
• W2108639775 cites W2397518918 @default.
• W2108639775 cites W2431513294 @default.
• W2108639775 cites W2774846296 @default.
• W2108639775 cites W312292187 @default.
• W2108639775 cites W2467610488 @default.
• W2108639775 doi "https://doi.org/10.1016/s1201-9712(10)60047-1" @default.
• W2108639775 hasPublicationYear "2010" @default.
• W2108639775 type Work @default.
• W2108639775 sameAs 2108639775 @default.
• W2108639775 citedByCount "5" @default.
• W2108639775 countsByYear W21086397752013 @default.
• W2108639775 countsByYear W21086397752017 @default.
• W2108639775 countsByYear W21086397752019 @default.
• W2108639775 countsByYear W21086397752021 @default.
• W2108639775 crossrefType "journal-article" @default.
• W2108639775 hasAuthorship W2108639775A5015297404 @default.
• W2108639775 hasAuthorship W2108639775A5025011346 @default.
• W2108639775 hasAuthorship W2108639775A5041147754 @default.
• W2108639775 hasAuthorship W2108639775A5059708249 @default.
• W2108639775 hasAuthorship W2108639775A5068012459 @default.
• W2108639775 hasAuthorship W2108639775A5075128025 @default.
• W2108639775 hasBestOaLocation W21086397751 @default.
• W2108639775 hasConcept C126322002 @default.
• W2108639775 hasConcept C159654299 @default.
• W2108639775 hasConcept C165901193 @default.
• W2108639775 hasConcept C203014093 @default.
• W2108639775 hasConcept C2776225656 @default.
• W2108639775 hasConcept C2776863245 @default.
• W2108639775 hasConcept C2778491710 @default.
• W2108639775 hasConcept C2779744950 @default.
• W2108639775 hasConcept C2780035454 @default.
• W2108639775 hasConcept C2780140890 @default.
• W2108639775 hasConcept C2780559512 @default.
• W2108639775 hasConcept C2780801004 @default.
• W2108639775 hasConcept C2780931953 @default.
• W2108639775 hasConcept C71924100 @default.
• W2108639775 hasConcept C8891405 @default.
• W2108639775 hasConcept C98274493 @default.
• W2108639775 hasConceptScore W2108639775C126322002 @default.
• W2108639775 hasConceptScore W2108639775C159654299 @default.
• W2108639775 hasConceptScore W2108639775C165901193 @default.
• W2108639775 hasConceptScore W2108639775C203014093 @default.
• W2108639775 hasConceptScore W2108639775C2776225656 @default.
• W2108639775 hasConceptScore W2108639775C2776863245 @default.
• W2108639775 hasConceptScore W2108639775C2778491710 @default.
• W2108639775 hasConceptScore W2108639775C2779744950 @default.
• W2108639775 hasConceptScore W2108639775C2780035454 @default.
• W2108639775 hasConceptScore W2108639775C2780140890 @default.
• W2108639775 hasConceptScore W2108639775C2780559512 @default.
• W2108639775 hasConceptScore W2108639775C2780801004 @default.
• W2108639775 hasConceptScore W2108639775C2780931953 @default.
• W2108639775 hasConceptScore W2108639775C71924100 @default.

• next