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- W2108642672 abstract "Benzoyl peroxide has been used for decades for the treatment of acne vulgaris in many different formulation types including benzoyl peroxide washes. The typical use of washes or cleansers involves application to the face and rinsing with water after a few seconds to minutes. Thus, the products are only in contact with the skin for a short time compared to other leave-on benzoyl peroxide acne products. The effectiveness of this short contact time to kill Propionibacterium acnes was recently investigated in an in vitro kill rate study. Four products were tested which contained benzoyl peroxide at 3%, 4%, 4%, and 5%, respectively, each in a different cleansing base. Each product was diluted 1:5 with TAT broth to which P. acnes were then added. After 20 second, 1 minute and 5 minute time intervals 1 g aliquots were removed, neutralized and plated for incubation. Colony forming units were counted after 4 days of incubation at 32-35°C under anaerobic conditions. One of the 4% benzoyl peroxide products, in a creamy wash base, showed superior antibacterial activity against P. acnes in this system compared to the other 4% benzoyl peroxide product and the 5% benzoyl peroxide product. The 3% product showed minimal antibacterial activity." @default.
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- W2108642672 date "2004-03-01" @default.
- W2108642672 modified "2023-09-27" @default.
- W2108642672 title "An in vitro kill rate study against p. acnes comparing four benzoyl peroxide washes" @default.
- W2108642672 doi "https://doi.org/10.1016/j.jaad.2003.10.087" @default.
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