FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108643578> ?p ?o ?g. }

• W2108643578 endingPage "e4250" @default.
• W2108643578 startingPage "e4250" @default.
• W2108643578 abstract "Background Previously, we reported that the “antioxidant” compound “mitoQ” (mitochondrial-targeted ubiquinol/ubiquinone) actually increased superoxide production by bovine aortic endothelial (BAE) cell mitochondria incubated with complex I but not complex II substrates. Methods and Results To further define the site of action of the targeted coenzyme Q compound, we extended these studies to include different substrate and inhibitor conditions. In addition, we assessed the effects of mitoquinone on mitochondrial respiration, measured respiration and mitochondrial membrane potential in intact cells, and tested the intriguing hypothesis that mitoquinone might impart fuel selectivity in intact BAE cells. In mitochondria respiring on differing concentrations of complex I substrates, mitoquinone and rotenone had interactive effects on ROS consistent with redox cycling at multiple sites within complex I. Mitoquinone increased respiration in isolated mitochondria respiring on complex I but not complex II substrates. Mitoquinone also increased oxygen consumption by intact BAE cells. Moreover, when added to intact cells at 50 to 1000 nM, mitoquinone increased glucose oxidation and reduced fat oxidation, at doses that did not alter membrane potential or induce cell toxicity. Although high dose mitoquinone reduced mitochondrial membrane potential, the positively charged mitochondrial-targeted cation, decyltriphenylphosphonium (mitoquinone without the coenzyme Q moiety), decreased membrane potential more than mitoquinone, but did not alter fuel selectivity. Therefore, non-specific effects of the positive charge were not responsible and the quinone moiety is required for altered nutrient selectivity. Conclusions In summary, the interactive effects of mitoquinone and rotenone are consistent with redox cycling at more than one site within complex I. In addition, mitoquinone has substrate dependent effects on mitochondrial respiration, increases repiration by intact cells, and alters fuel selectivity favoring glucose over fatty acid oxidation at the intact cell level." @default.
• W2108643578 created "2016-06-24" @default.
• W2108643578 creator A5029294255 @default.
• W2108643578 creator A5032808557 @default.
• W2108643578 creator A5035496277 @default.
• W2108643578 creator A5039002796 @default.
• W2108643578 creator A5044922249 @default.
• W2108643578 creator A5055273664 @default.
• W2108643578 date "2009-01-22" @default.
• W2108643578 modified "2023-09-24" @default.
• W2108643578 title "Mitochondrial Targeted Coenzyme Q, Superoxide, and Fuel Selectivity in Endothelial Cells" @default.
• W2108643578 cites W1529592271 @default.
• W2108643578 cites W1554017667 @default.
• W2108643578 cites W1567637492 @default.
• W2108643578 cites W1657478053 @default.
• W2108643578 cites W1813230101 @default.
• W2108643578 cites W1963916684 @default.
• W2108643578 cites W1964991169 @default.
• W2108643578 cites W1969628253 @default.
• W2108643578 cites W1971215002 @default.
• W2108643578 cites W1986956461 @default.
• W2108643578 cites W1987325894 @default.
• W2108643578 cites W1996885665 @default.
• W2108643578 cites W2002529150 @default.
• W2108643578 cites W2002625920 @default.
• W2108643578 cites W2008404156 @default.
• W2108643578 cites W2017692041 @default.
• W2108643578 cites W2027059985 @default.
• W2108643578 cites W2036127346 @default.
• W2108643578 cites W2043243208 @default.
• W2108643578 cites W2044142994 @default.
• W2108643578 cites W2046601184 @default.
• W2108643578 cites W2052673116 @default.
• W2108643578 cites W2066290187 @default.
• W2108643578 cites W2070647639 @default.
• W2108643578 cites W2077120170 @default.
• W2108643578 cites W2078341577 @default.
• W2108643578 cites W2079793296 @default.
• W2108643578 cites W2086896843 @default.
• W2108643578 cites W2102326852 @default.
• W2108643578 cites W2102916729 @default.
• W2108643578 cites W2104865391 @default.
• W2108643578 cites W2109818274 @default.
• W2108643578 cites W2113007696 @default.
• W2108643578 cites W2123105661 @default.
• W2108643578 cites W2128569391 @default.
• W2108643578 cites W2130210612 @default.
• W2108643578 cites W2132826785 @default.
• W2108643578 cites W2142734267 @default.
• W2108643578 cites W2147081499 @default.
• W2108643578 cites W2154385453 @default.
• W2108643578 cites W2155167730 @default.
• W2108643578 cites W2168695851 @default.
• W2108643578 cites W2336445431 @default.
• W2108643578 cites W2468150319 @default.
• W2108643578 cites W4211211676 @default.
• W2108643578 doi "https://doi.org/10.1371/journal.pone.0004250" @default.
• W2108643578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2621344" @default.
• W2108643578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19158951" @default.
• W2108643578 hasPublicationYear "2009" @default.
• W2108643578 type Work @default.
• W2108643578 sameAs 2108643578 @default.
• W2108643578 citedByCount "19" @default.
• W2108643578 countsByYear W21086435782012 @default.
• W2108643578 countsByYear W21086435782013 @default.
• W2108643578 countsByYear W21086435782014 @default.
• W2108643578 countsByYear W21086435782016 @default.
• W2108643578 countsByYear W21086435782017 @default.
• W2108643578 countsByYear W21086435782018 @default.
• W2108643578 countsByYear W21086435782019 @default.
• W2108643578 countsByYear W21086435782020 @default.
• W2108643578 countsByYear W21086435782021 @default.
• W2108643578 crossrefType "journal-article" @default.
• W2108643578 hasAuthorship W2108643578A5029294255 @default.
• W2108643578 hasAuthorship W2108643578A5032808557 @default.
• W2108643578 hasAuthorship W2108643578A5035496277 @default.
• W2108643578 hasAuthorship W2108643578A5039002796 @default.
• W2108643578 hasAuthorship W2108643578A5044922249 @default.
• W2108643578 hasAuthorship W2108643578A5055273664 @default.
• W2108643578 hasBestOaLocation W21086435781 @default.
• W2108643578 hasConcept C100206155 @default.
• W2108643578 hasConcept C12554922 @default.
• W2108643578 hasConcept C14471203 @default.
• W2108643578 hasConcept C178790620 @default.
• W2108643578 hasConcept C181199279 @default.
• W2108643578 hasConcept C181911157 @default.
• W2108643578 hasConcept C182215343 @default.
• W2108643578 hasConcept C185592680 @default.
• W2108643578 hasConcept C2778175917 @default.
• W2108643578 hasConcept C2778389096 @default.
• W2108643578 hasConcept C2778777121 @default.
• W2108643578 hasConcept C2780795997 @default.
• W2108643578 hasConcept C28859421 @default.
• W2108643578 hasConcept C29311851 @default.
• W2108643578 hasConcept C48349386 @default.
• W2108643578 hasConcept C55493867 @default.
• W2108643578 hasConcept C55904794 @default.
• W2108643578 hasConcept C57600042 @default.

• next