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• W2108644512 startingPage "605" @default.
• W2108644512 abstract "In the AAA+ ClpXP protease, ClpX uses repeated cycles of ATP hydrolysis to pull native proteins apart and to translocate the denatured polypeptide into ClpP for degradation. Here, we probe polypeptide features important for translocation. ClpXP degrades diverse synthetic peptide substrates despite major differences in side-chain chirality, size, and polarity. Moreover, translocation occurs without a peptide -NH and with 10 methylenes between successive peptide bonds. Pulling on homopolymeric tracts of glycine, proline, and lysine also allows efficient ClpXP degradation of a stably folded protein. Thus, minimal chemical features of a polypeptide chain are sufficient for translocation and protein unfolding by the ClpX machine. These results suggest that the translocation pore of ClpX is highly elastic, allowing interactions with a wide range of chemical groups, a feature likely to be shared by many AAA+ unfoldases." @default.
• W2108644512 created "2016-06-24" @default.
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• W2108644512 date "2009-06-01" @default.
• W2108644512 modified "2023-09-27" @default.
• W2108644512 title "Polypeptide Translocation by the AAA+ ClpXP Protease Machine" @default.
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• W2108644512 doi "https://doi.org/10.1016/j.chembiol.2009.05.007" @default.
• W2108644512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2718738" @default.
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