FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108648814> ?p ?o ?g. }

• W2108648814 endingPage "H1514" @default.
• W2108648814 startingPage "H1505" @default.
• W2108648814 abstract "Little is known about the role of mitochondrial NADP(+)-isocitrate dehydrogenase (NADP(+)-ICDH) in the heart, where this enzyme shows its highest expression and activity. We tested the hypothesis that in the heart, NADP(+)-ICDH operates in the reverse direction of the citric acid cycle (CAC) and thereby may contribute to the fine regulation of CAC activity (Sazanov and Jackson, FEBS Lett 344: 109-116, 1994). We documented a reverse flux through this enzyme in rat hearts perfused with the medium-chain fatty acid octanoate using [U-(13)C(5)]glutamate and mass isotopomer analysis of tissue citrate (Comte et al., J Biol Chem 272: 26117-26124, 1997). In this study, we assessed the significance of our previous finding by perfusing hearts with long-chain fatty acids and tested the effects of changes in O(2) supply. We showed that under all of these conditions citrate was enriched in an isotopomer containing five (13)C atoms. This isotopomer can only be explained by substrate flux through reversal of the NADP(+)-ICDH reaction, which is evaluated at 3-7% of flux through citrate synthase. Small variations in reversal fluxes induced by low-flow ischemia that mimicked hibernation occurred despite major changes in contractile function and O(2) consumption of the heart as well as citrate and succinate release rates and tissue levels. Our data show a reverse flux through NADP(+)-ICDH and support its hypothesized role in the fine regulation of CAC activity in the normoxic and O(2)-deprived heart." @default.
• W2108648814 created "2016-06-24" @default.
• W2108648814 creator A5020011946 @default.
• W2108648814 creator A5035574153 @default.
• W2108648814 creator A5050899901 @default.
• W2108648814 creator A5088257611 @default.
• W2108648814 creator A5090984354 @default.
• W2108648814 date "2002-10-01" @default.
• W2108648814 modified "2023-10-03" @default.
• W2108648814 title "Reverse flux through cardiac NADP⁺-isocitrate dehydrogenase under normoxia and ischemia" @default.
• W2108648814 cites W1063595 @default.
• W2108648814 cites W1523008440 @default.
• W2108648814 cites W1566413889 @default.
• W2108648814 cites W1693234450 @default.
• W2108648814 cites W1811132283 @default.
• W2108648814 cites W1872148344 @default.
• W2108648814 cites W1916510256 @default.
• W2108648814 cites W1949169782 @default.
• W2108648814 cites W1967763397 @default.
• W2108648814 cites W1968221390 @default.
• W2108648814 cites W1978870919 @default.
• W2108648814 cites W1985259535 @default.
• W2108648814 cites W1992640393 @default.
• W2108648814 cites W1994264539 @default.
• W2108648814 cites W1996736495 @default.
• W2108648814 cites W2003081449 @default.
• W2108648814 cites W2005093036 @default.
• W2108648814 cites W2016066239 @default.
• W2108648814 cites W2023452995 @default.
• W2108648814 cites W2031518757 @default.
• W2108648814 cites W2052927700 @default.
• W2108648814 cites W2072361374 @default.
• W2108648814 cites W2072885613 @default.
• W2108648814 cites W2074978715 @default.
• W2108648814 cites W2082749260 @default.
• W2108648814 cites W2085117641 @default.
• W2108648814 cites W2086592297 @default.
• W2108648814 cites W2090680866 @default.
• W2108648814 cites W2097800631 @default.
• W2108648814 cites W2098978387 @default.
• W2108648814 cites W2131960328 @default.
• W2108648814 cites W2158330490 @default.
• W2108648814 cites W2187662384 @default.
• W2108648814 cites W2189690655 @default.
• W2108648814 cites W2398652950 @default.
• W2108648814 cites W2400213213 @default.
• W2108648814 cites W2415439429 @default.
• W2108648814 cites W2415721714 @default.
• W2108648814 cites W331981547 @default.
• W2108648814 cites W4246601434 @default.
• W2108648814 doi "https://doi.org/10.1152/ajpheart.00287.2002" @default.
• W2108648814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12234803" @default.
• W2108648814 hasPublicationYear "2002" @default.
• W2108648814 type Work @default.
• W2108648814 sameAs 2108648814 @default.
• W2108648814 citedByCount "64" @default.
• W2108648814 countsByYear W21086488142012 @default.
• W2108648814 countsByYear W21086488142013 @default.
• W2108648814 countsByYear W21086488142014 @default.
• W2108648814 countsByYear W21086488142015 @default.
• W2108648814 countsByYear W21086488142016 @default.
• W2108648814 countsByYear W21086488142019 @default.
• W2108648814 countsByYear W21086488142020 @default.
• W2108648814 countsByYear W21086488142021 @default.
• W2108648814 countsByYear W21086488142022 @default.
• W2108648814 crossrefType "journal-article" @default.
• W2108648814 hasAuthorship W2108648814A5020011946 @default.
• W2108648814 hasAuthorship W2108648814A5035574153 @default.
• W2108648814 hasAuthorship W2108648814A5050899901 @default.
• W2108648814 hasAuthorship W2108648814A5088257611 @default.
• W2108648814 hasAuthorship W2108648814A5090984354 @default.
• W2108648814 hasConcept C111133373 @default.
• W2108648814 hasConcept C127124265 @default.
• W2108648814 hasConcept C165135838 @default.
• W2108648814 hasConcept C178790620 @default.
• W2108648814 hasConcept C181199279 @default.
• W2108648814 hasConcept C185592680 @default.
• W2108648814 hasConcept C2776317432 @default.
• W2108648814 hasConcept C2777150147 @default.
• W2108648814 hasConcept C32909587 @default.
• W2108648814 hasConcept C55493867 @default.
• W2108648814 hasConcept C68709404 @default.
• W2108648814 hasConcept C86803240 @default.
• W2108648814 hasConceptScore W2108648814C111133373 @default.
• W2108648814 hasConceptScore W2108648814C127124265 @default.
• W2108648814 hasConceptScore W2108648814C165135838 @default.
• W2108648814 hasConceptScore W2108648814C178790620 @default.
• W2108648814 hasConceptScore W2108648814C181199279 @default.
• W2108648814 hasConceptScore W2108648814C185592680 @default.
• W2108648814 hasConceptScore W2108648814C2776317432 @default.
• W2108648814 hasConceptScore W2108648814C2777150147 @default.
• W2108648814 hasConceptScore W2108648814C32909587 @default.
• W2108648814 hasConceptScore W2108648814C55493867 @default.
• W2108648814 hasConceptScore W2108648814C68709404 @default.
• W2108648814 hasConceptScore W2108648814C86803240 @default.
• W2108648814 hasIssue "4" @default.
• W2108648814 hasLocation W21086488141 @default.
• W2108648814 hasLocation W21086488142 @default.

• next