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• W2108649989 endingPage "642" @default.
• W2108649989 startingPage "633" @default.
• W2108649989 abstract "Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic and pharmacodynamic features of this drug. Considering the pharmacokinetics of levodopa and the factors that can modify it are essential for the clinician when prescribing levodopa products in order to maximize their therapeutic effects.This paper reviews the studies carried out evaluating the interaction between levodopa and dietary factors.The reader will gain a greater understanding of the different dietary factors that can affect levodopa pharmacokinetics and, thus, the therapeutic response that is obtained with this drug in several situations.An understanding of the pharmacokinetics of any drug is crucial for the establishment of its optimal therapeutic regimen, but this assumes a special importance with levodopa, due to its extensive presystemic metabolism, rapid absorption in the proximal small intestine and short plasma half-life. Major problems with levodopa treatment are the fluctuations in clinical response experienced in patients with advanced Parkinson's disease that sometimes are related to the peripheral pharmacokinetics of levodopa. Studies of levodopa interactions are very important to improve patient response to this drug." @default.
• W2108649989 created "2016-06-24" @default.
• W2108649989 creator A5010932701 @default.
• W2108649989 creator A5027598706 @default.
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• W2108649989 creator A5047657582 @default.
• W2108649989 creator A5070092313 @default.
• W2108649989 creator A5088176779 @default.
• W2108649989 date "2010-04-13" @default.
• W2108649989 modified "2023-10-18" @default.
• W2108649989 title "Effects of dietary factors on levodopa pharmacokinetics" @default.
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