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• W2108651075 abstract "Abstract Purpose To assess the clinical feasibility of magnetic resonance (MR) imaging with a mechanical loading system for evaluation of load‐bearing function in knee joints using cartilage T2 as a surrogate of cartilage matrix changes. Materials and Methods Sagittal T2 maps of the medial and lateral femorotibial joints of 22 healthy volunteers were obtained using 3.0T MR imaging. After preloading for 6–9 minutes, MR images under static loading conditions were obtained by applying axial compression force of 50% of body weight during imaging. T2 values of the femoral and tibial cartilage at the weight‐bearing area were compared between unloading and loading conditions. Results Under loading conditions, mean cartilage T2 decreased, depending on location of the knee cartilage. For the femoral side a significant decrease in T2 with loading was observed only at the region in direct contact with the opposing tibial cartilage, in the medial femoral cartilage (5.4%, P < 0.0005). For the tibial side a significant decrease in T2 with loading was widely observed in the medial and lateral joint, at regions both covered and not covered by the meniscus (4.3%–7.6%, P < 0.005). Conclusion MR imaging with mechanical loading is feasible to detect site‐specific changes in cartilage T2 during static loading. J. Magn. Reson. Imaging 2008;28:175–180. © 2008 Wiley‐Liss, Inc." @default.
• W2108651075 created "2016-06-24" @default.
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• W2108651075 date "2008-06-25" @default.
• W2108651075 modified "2023-10-18" @default.
• W2108651075 title "Change in knee cartilage T2 in response to mechanical loading" @default.
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• W2108651075 doi "https://doi.org/10.1002/jmri.21418" @default.
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