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• W2108652316 endingPage "C289" @default.
• W2108652316 startingPage "C276" @default.
• W2108652316 abstract "Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 ( TRPC6) gene and mutations in the NPHS2 gene encoding podocin result in nephrotic syndromes. The purpose of this study was to determine the functional significance of biochemical interactions between these proteins. We observed that gating of TRPC6 channels in podocytes is markedly mechanosensitive and can be activated by hyposmotic stretch or indentation of the plasma membrane. Stretch activation of cationic currents was blocked by small interfering RNA knockdown of TRPC6, as well as by SKF-96365 or micromolar La 3+ . Stretch activation of podocyte TRPC6 persisted in the presence of inhibitors of phospholipase C (U-73122) and phospholipase A 2 (ONO-RS-082). Robust stretch responses also persisted when recording electrodes contained guanosine 5′- O-(2-thiodiphosphate) at concentrations that completely suppressed responses to ANG II. Stretch responses were enhanced by cytochalasin D but were abolished by the peptide GsMTx4, suggesting that forces are transmitted to the channels through the plasma membrane. Podocin and TRPC6 interact at their respective COOH termini. Knockdown of podocin markedly increased stretch-evoked activation of TRPC6 but nearly abolished TRPC6 activation evoked by a diacylglycerol analog. These data suggest that podocin acts as a switch to determine the preferred mode of TRPC6 activation. They also suggest that podocin deficiencies will result in Ca 2+ overload in foot processes, as with gain-of-function mutations in the TRPC6 gene. Finally, they suggest that mechanical activation of TRP family channels and the preferred mode of TRP channel activation may depend on whether members of the stomatin/prohibitin family of hairpin loop proteins are present." @default.
• W2108652316 created "2016-06-24" @default.
• W2108652316 creator A5010970363 @default.
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• W2108652316 creator A5032711040 @default.
• W2108652316 creator A5038755274 @default.
• W2108652316 creator A5050423319 @default.
• W2108652316 date "2013-08-01" @default.
• W2108652316 modified "2023-10-17" @default.
• W2108652316 title "Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol" @default.
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• W2108652316 doi "https://doi.org/10.1152/ajpcell.00095.2013" @default.
• W2108652316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23657570" @default.
• W2108652316 hasPublicationYear "2013" @default.
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