Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108655462> ?p ?o ?g. }
- W2108655462 endingPage "3393" @default.
- W2108655462 startingPage "3379" @default.
- W2108655462 abstract "Cellular stress can globally inhibit translation initiation, and glucose removal from yeast causes one of the most dramatic effects in terms of rapidity and scale. Here we show that the same rapid inhibition occurs during yeast growth as glucose levels diminish. We characterize this novel regulation showing that it involves alterations within the 48S preinitiation complex. In particular, the interaction between eIF4A and eIF4G is destabilized, leading to a temporary stabilization of the eIF3–eIF4G interaction on the 48S complex. Under such conditions, specific mRNAs that are important for the adaptation to the new conditions must continue to be translated. We have determined which mRNAs remain translated early after glucose starvation. These experiments enable us to provide a physiological context for this translational regulation by ascribing defined functions that are translationally maintained or up-regulated. Overrepresented in this class of mRNA are those involved in carbohydrate metabolism, including several mRNAs from the pentose phosphate pathway. Our data support a hypothesis that a concerted preemptive activation of the pentose phosphate pathway, which targets both mRNA transcription and translation, is important for the transition from fermentative to respiratory growth in yeast." @default.
- W2108655462 created "2016-06-24" @default.
- W2108655462 creator A5004160157 @default.
- W2108655462 creator A5011906523 @default.
- W2108655462 creator A5013389988 @default.
- W2108655462 creator A5017312818 @default.
- W2108655462 creator A5023175028 @default.
- W2108655462 creator A5045213431 @default.
- W2108655462 creator A5056894026 @default.
- W2108655462 creator A5071550154 @default.
- W2108655462 creator A5077440888 @default.
- W2108655462 creator A5079603219 @default.
- W2108655462 creator A5081254866 @default.
- W2108655462 date "2011-09-15" @default.
- W2108655462 modified "2023-10-16" @default.
- W2108655462 title "Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated" @default.
- W2108655462 cites W1532417550 @default.
- W2108655462 cites W1763659965 @default.
- W2108655462 cites W1817433838 @default.
- W2108655462 cites W1964895626 @default.
- W2108655462 cites W1972243502 @default.
- W2108655462 cites W1993649868 @default.
- W2108655462 cites W2002391903 @default.
- W2108655462 cites W2002416071 @default.
- W2108655462 cites W2004143350 @default.
- W2108655462 cites W2008410413 @default.
- W2108655462 cites W2009994916 @default.
- W2108655462 cites W2016107719 @default.
- W2108655462 cites W2022141676 @default.
- W2108655462 cites W2027821655 @default.
- W2108655462 cites W2028022492 @default.
- W2108655462 cites W2038991604 @default.
- W2108655462 cites W2048105864 @default.
- W2108655462 cites W2048263532 @default.
- W2108655462 cites W2065234774 @default.
- W2108655462 cites W2070085869 @default.
- W2108655462 cites W2070681399 @default.
- W2108655462 cites W2075511135 @default.
- W2108655462 cites W2076120836 @default.
- W2108655462 cites W2076930068 @default.
- W2108655462 cites W2081098333 @default.
- W2108655462 cites W2081827055 @default.
- W2108655462 cites W2084119410 @default.
- W2108655462 cites W2086079901 @default.
- W2108655462 cites W2093158584 @default.
- W2108655462 cites W2099377713 @default.
- W2108655462 cites W2102759838 @default.
- W2108655462 cites W2105630360 @default.
- W2108655462 cites W2109535551 @default.
- W2108655462 cites W2109652338 @default.
- W2108655462 cites W2110453129 @default.
- W2108655462 cites W2115585439 @default.
- W2108655462 cites W2115897170 @default.
- W2108655462 cites W2116592258 @default.
- W2108655462 cites W2117954597 @default.
- W2108655462 cites W2121401282 @default.
- W2108655462 cites W2123742352 @default.
- W2108655462 cites W2124787195 @default.
- W2108655462 cites W2129183636 @default.
- W2108655462 cites W2132432514 @default.
- W2108655462 cites W2136433399 @default.
- W2108655462 cites W2141200742 @default.
- W2108655462 cites W2141325721 @default.
- W2108655462 cites W2147211787 @default.
- W2108655462 cites W2150924675 @default.
- W2108655462 cites W2151102421 @default.
- W2108655462 cites W2151574291 @default.
- W2108655462 cites W2152946648 @default.
- W2108655462 cites W2154046032 @default.
- W2108655462 cites W2155639426 @default.
- W2108655462 cites W2157258464 @default.
- W2108655462 cites W2158842667 @default.
- W2108655462 cites W2159223313 @default.
- W2108655462 cites W2160012273 @default.
- W2108655462 cites W2160697532 @default.
- W2108655462 cites W2165011536 @default.
- W2108655462 cites W2171283475 @default.
- W2108655462 cites W4238138998 @default.
- W2108655462 doi "https://doi.org/10.1091/mbc.e11-02-0153" @default.
- W2108655462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172263" @default.
- W2108655462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21795399" @default.
- W2108655462 hasPublicationYear "2011" @default.
- W2108655462 type Work @default.
- W2108655462 sameAs 2108655462 @default.
- W2108655462 citedByCount "80" @default.
- W2108655462 countsByYear W21086554622012 @default.
- W2108655462 countsByYear W21086554622013 @default.
- W2108655462 countsByYear W21086554622014 @default.
- W2108655462 countsByYear W21086554622015 @default.
- W2108655462 countsByYear W21086554622016 @default.
- W2108655462 countsByYear W21086554622017 @default.
- W2108655462 countsByYear W21086554622018 @default.
- W2108655462 countsByYear W21086554622019 @default.
- W2108655462 countsByYear W21086554622020 @default.
- W2108655462 countsByYear W21086554622021 @default.
- W2108655462 countsByYear W21086554622022 @default.
- W2108655462 countsByYear W21086554622023 @default.
- W2108655462 crossrefType "journal-article" @default.