Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108657306> ?p ?o ?g. }
- W2108657306 abstract "Neuromodulators alter network output and have the potential to destabilize a circuit. The mechanisms maintaining stability in the face of neuromodulation are not well described. Using the pyloric network in the crustacean stomatogastric nervous system, we show that dopamine (DA) does not simply alter circuit output, but activates a closed loop in which DA-induced alterations in circuit output consequently drive a change in an ionic conductance to preserve a conductance ratio and its activity correlate. DA acted at low affinity type 1 receptors (D1Rs) to induce an immediate modulatory decrease in the transient potassium current (IA) of a pyloric neuron. This, in turn, advanced the activity phase of that component neuron, which disrupted its network function and thereby destabilized the circuit. DA simultaneously acted at high affinity D1Rs on the same neuron to confer activity-dependence upon the hyperpolarization activated current (Ih) such that the DA-induced changes in activity subsequently reduced Ih. This DA-enabled, activity-dependent, intrinsic plasticity exactly compensated for the modulatory decrease in IA to restore the IA:Ih ratio and neuronal activity phase, thereby closing an open loop created by the modulator. Activation of closed loops to preserve conductance ratios may represent a fundamental operating principle neuromodulatory systems use to ensure stability in their target networks." @default.
- W2108657306 created "2016-06-24" @default.
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- W2108657306 date "2013-01-01" @default.
- W2108657306 modified "2023-09-27" @default.
- W2108657306 title "Activation of high and low affinity dopamine receptors generates a closed loop that maintains a conductance ratio and its activity correlate" @default.
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- W2108657306 doi "https://doi.org/10.3389/fncir.2013.00169" @default.
- W2108657306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3805135" @default.
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