FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108664114> ?p ?o ?g. }

• W2108664114 endingPage "S631" @default.
• W2108664114 startingPage "S630" @default.
• W2108664114 abstract "Adult T-cell leukemia/lymphoma (ATL) is a rare malignancy associated with chronic infection with human T-cell leukemia virus type 1. It is most often seen in Africa, the Caribbean basin, Southwestern Japan and African-Americans in Southeastern United States. Patients (pts) with acute or lymphomatous type ATL usually have survivals limited to a few months, whereas pts with chronic or smoldering ATL can achieve more prolonged survivals. ATL is typically managed with multi-drug chemotherapy. Only one prior series (Baba et al. 1994), however, has assessed the role of localized radiation therapy (RT) in the management of ATL. This retrospective study examined treatment courses of 10 consecutive pts with pathologically-confirmed ATL treated with RT at the National Institutes of Health from 1997 - 2010. Pts were Afro-Caribbean (9 Jamaican, 1 Haitian), predominantly female (n = 9) and a mean of 48.3 yrs old (range 31 - 65 yrs) at the time of RT. They had acute (n = 7), smoldering (n = 2) or lymphomatous (n = 1) type ATL. They failed an average of 2.5 prior courses of systemic chemotherapies (range 1 - 4) prior to receiving RT at a mean of 12.3 mo (range 5 - 24 mo) after their ATL diagnosis. In total, 17 lesions were treated, all of which were symptomatic. Pts received RT to lymph node masses (9 lesions) or cutaneous (7) or non-cutaneous extranodal (1) disease. Lesions were treated using two-field photon (12) or en face electron (5) RT to a mean dose of 32.2 Gy (range 12 - 60 Gy) in 2.5 Gy fractions (range 2 - 3 Gy). All pts reported symptomatic improvement. At a mean follow-up of 5.1 months (range 0.1 - 18.1 mo), radiographic or clinical response to RT was achieved in all 17 lesions, with partial response in 71% and complete response (CR) in 29% (nodal CR 33% vs. cutaneous CR 29%, p = 0.85). No pt experienced in-field disease progression (0/17 lesions). Four pts developed out-of-field progression, three developed new distant disease and four received multi-drug chemotherapy following RT. Three pts died from disease progression (two deaths within one month of RT completion). Pts experienced RTOG acute grade 1 (n = 1) or grade 2 (n = 2) toxicity. No pt suffered acute grade ≥3 or any RTOG/EORTC late grade ≥1 toxicity. Although multiple subtypes of ATL were evaluated and follow-up was limited due to pt deaths or pts lost to follow-up returning to Jamaica, this study is one of the largest assessing RT to treat or palliate pts with ATL. This study demonstrated that RT can achieve excellent local control and symptomatic improvement across lesion types and ATL subtypes. As ATL is often refractory to systemic therapy, multi-modality therapy is necessary. Radiation therapy in this pt population may be underutilized and should be considered for pts with local disease progression and symptoms." @default.
• W2108664114 created "2016-06-24" @default.
• W2108664114 creator A5001021073 @default.
• W2108664114 creator A5021164683 @default.
• W2108664114 creator A5023505083 @default.
• W2108664114 creator A5025737516 @default.
• W2108664114 creator A5035263938 @default.
• W2108664114 creator A5037223246 @default.
• W2108664114 creator A5078406062 @default.
• W2108664114 creator A5084546714 @default.
• W2108664114 date "2011-10-01" @default.
• W2108664114 modified "2023-10-16" @default.
• W2108664114 title "Radiation Therapy for Management of Patients with HTLV-1-associated Adult T-cell Leukemia/Lymphoma" @default.
• W2108664114 doi "https://doi.org/10.1016/j.ijrobp.2011.06.1874" @default.
• W2108664114 hasPublicationYear "2011" @default.
• W2108664114 type Work @default.
• W2108664114 sameAs 2108664114 @default.
• W2108664114 citedByCount "0" @default.
• W2108664114 crossrefType "journal-article" @default.
• W2108664114 hasAuthorship W2108664114A5001021073 @default.
• W2108664114 hasAuthorship W2108664114A5021164683 @default.
• W2108664114 hasAuthorship W2108664114A5023505083 @default.
• W2108664114 hasAuthorship W2108664114A5025737516 @default.
• W2108664114 hasAuthorship W2108664114A5035263938 @default.
• W2108664114 hasAuthorship W2108664114A5037223246 @default.
• W2108664114 hasAuthorship W2108664114A5078406062 @default.
• W2108664114 hasAuthorship W2108664114A5084546714 @default.
• W2108664114 hasConcept C126322002 @default.
• W2108664114 hasConcept C2776694085 @default.
• W2108664114 hasConcept C2776913467 @default.
• W2108664114 hasConcept C2778461978 @default.
• W2108664114 hasConcept C2779338263 @default.
• W2108664114 hasConcept C2779399171 @default.
• W2108664114 hasConcept C2780815077 @default.
• W2108664114 hasConcept C2780849966 @default.
• W2108664114 hasConcept C509974204 @default.
• W2108664114 hasConcept C71924100 @default.
• W2108664114 hasConcept C90924648 @default.
• W2108664114 hasConceptScore W2108664114C126322002 @default.
• W2108664114 hasConceptScore W2108664114C2776694085 @default.
• W2108664114 hasConceptScore W2108664114C2776913467 @default.
• W2108664114 hasConceptScore W2108664114C2778461978 @default.
• W2108664114 hasConceptScore W2108664114C2779338263 @default.
• W2108664114 hasConceptScore W2108664114C2779399171 @default.
• W2108664114 hasConceptScore W2108664114C2780815077 @default.
• W2108664114 hasConceptScore W2108664114C2780849966 @default.
• W2108664114 hasConceptScore W2108664114C509974204 @default.
• W2108664114 hasConceptScore W2108664114C71924100 @default.
• W2108664114 hasConceptScore W2108664114C90924648 @default.
• W2108664114 hasIssue "2" @default.
• W2108664114 hasLocation W21086641141 @default.
• W2108664114 hasOpenAccess W2108664114 @default.
• W2108664114 hasPrimaryLocation W21086641141 @default.
• W2108664114 hasRelatedWork W1888111113 @default.
• W2108664114 hasRelatedWork W1997676430 @default.
• W2108664114 hasRelatedWork W2002137228 @default.
• W2108664114 hasRelatedWork W2032965398 @default.
• W2108664114 hasRelatedWork W2088821386 @default.
• W2108664114 hasRelatedWork W2093379801 @default.
• W2108664114 hasRelatedWork W2101610405 @default.
• W2108664114 hasRelatedWork W2133647949 @default.
• W2108664114 hasRelatedWork W4251169518 @default.
• W2108664114 hasRelatedWork W4320032500 @default.
• W2108664114 hasVolume "81" @default.
• W2108664114 isParatext "false" @default.
• W2108664114 isRetracted "false" @default.
• W2108664114 magId "2108664114" @default.
• W2108664114 workType "article" @default.