Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108665093> ?p ?o ?g. }
- W2108665093 endingPage "954" @default.
- W2108665093 startingPage "935" @default.
- W2108665093 abstract "Prevention of skipping of exon 7 during pre-mRNA splicing of Survival Motor Neuron 2 (SMN2) holds the promise for cure of spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. Here, we report T-cell-restricted intracellular antigen 1 (TIA1) and TIA1-related (TIAR) proteins as intron-associated positive regulators of SMN2 exon 7 splicing. We show that TIA1/TIAR stimulate exon recognition in an entirely novel context in which intronic U-rich motifs are separated from the 5′ splice site by overlapping inhibitory elements. TIA1 and TIAR are modular proteins with three N-terminal RNA recognition motifs (RRMs) and a C-terminal glutamine-rich (Q-rich) domain. Our results reveal that any one RRM in combination with a Q domain is necessary and sufficient for TIA1-associated regulation of SMN2 exon 7 splicing in vivo. We also show that increased expression of TIA1 counteracts the inhibitory effect of polypyrimidine tract binding protein, a ubiquitously expressed factor recently implicated in regulation of SMN exon 7 splicing. Our findings expand the scope of TIA1/TIAR in genome-wide regulation of alternative splicing under normal and pathological conditions." @default.
- W2108665093 created "2016-06-24" @default.
- W2108665093 creator A5004611185 @default.
- W2108665093 creator A5015220134 @default.
- W2108665093 creator A5031182827 @default.
- W2108665093 creator A5032823939 @default.
- W2108665093 creator A5061593500 @default.
- W2108665093 creator A5086288935 @default.
- W2108665093 date "2011-03-01" @default.
- W2108665093 modified "2023-10-17" @default.
- W2108665093 title "TIA1 Prevents Skipping of a Critical Exon Associated with Spinal Muscular Atrophy" @default.
- W2108665093 cites W1504845338 @default.
- W2108665093 cites W1964072966 @default.
- W2108665093 cites W1974898488 @default.
- W2108665093 cites W1977201375 @default.
- W2108665093 cites W1977595548 @default.
- W2108665093 cites W1979937961 @default.
- W2108665093 cites W1987441541 @default.
- W2108665093 cites W1987687980 @default.
- W2108665093 cites W1990393476 @default.
- W2108665093 cites W1994332890 @default.
- W2108665093 cites W1994940904 @default.
- W2108665093 cites W1995239307 @default.
- W2108665093 cites W1998133732 @default.
- W2108665093 cites W1998834713 @default.
- W2108665093 cites W2002844327 @default.
- W2108665093 cites W2003151628 @default.
- W2108665093 cites W2007526989 @default.
- W2108665093 cites W2015809578 @default.
- W2108665093 cites W2016275728 @default.
- W2108665093 cites W2020164044 @default.
- W2108665093 cites W2024685343 @default.
- W2108665093 cites W2037206899 @default.
- W2108665093 cites W2046808917 @default.
- W2108665093 cites W2047332793 @default.
- W2108665093 cites W2054380003 @default.
- W2108665093 cites W2054696719 @default.
- W2108665093 cites W2059293195 @default.
- W2108665093 cites W2063530272 @default.
- W2108665093 cites W2076495609 @default.
- W2108665093 cites W2083827172 @default.
- W2108665093 cites W2087744052 @default.
- W2108665093 cites W2089878023 @default.
- W2108665093 cites W2091741479 @default.
- W2108665093 cites W2095998476 @default.
- W2108665093 cites W2097843267 @default.
- W2108665093 cites W2097956925 @default.
- W2108665093 cites W2104412616 @default.
- W2108665093 cites W2105394513 @default.
- W2108665093 cites W2105989886 @default.
- W2108665093 cites W2106154073 @default.
- W2108665093 cites W2108430210 @default.
- W2108665093 cites W2112926594 @default.
- W2108665093 cites W2113525941 @default.
- W2108665093 cites W2113917007 @default.
- W2108665093 cites W2116185451 @default.
- W2108665093 cites W2117660195 @default.
- W2108665093 cites W2119003967 @default.
- W2108665093 cites W2119045816 @default.
- W2108665093 cites W2119219430 @default.
- W2108665093 cites W2122183801 @default.
- W2108665093 cites W2124144440 @default.
- W2108665093 cites W2129670085 @default.
- W2108665093 cites W2132295996 @default.
- W2108665093 cites W2132451711 @default.
- W2108665093 cites W2137614382 @default.
- W2108665093 cites W2141009191 @default.
- W2108665093 cites W2143873927 @default.
- W2108665093 cites W2145237484 @default.
- W2108665093 cites W2145606896 @default.
- W2108665093 cites W2147898060 @default.
- W2108665093 cites W2149541702 @default.
- W2108665093 cites W2152444475 @default.
- W2108665093 cites W2152766938 @default.
- W2108665093 cites W2153279694 @default.
- W2108665093 cites W2158020008 @default.
- W2108665093 cites W2161486924 @default.
- W2108665093 cites W2167256464 @default.
- W2108665093 cites W2170702502 @default.
- W2108665093 cites W33784104 @default.
- W2108665093 cites W46722564 @default.
- W2108665093 doi "https://doi.org/10.1128/mcb.00945-10" @default.
- W2108665093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3067828" @default.
- W2108665093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21189287" @default.
- W2108665093 hasPublicationYear "2011" @default.
- W2108665093 type Work @default.
- W2108665093 sameAs 2108665093 @default.
- W2108665093 citedByCount "74" @default.
- W2108665093 countsByYear W21086650932012 @default.
- W2108665093 countsByYear W21086650932013 @default.
- W2108665093 countsByYear W21086650932014 @default.
- W2108665093 countsByYear W21086650932015 @default.
- W2108665093 countsByYear W21086650932016 @default.
- W2108665093 countsByYear W21086650932017 @default.
- W2108665093 countsByYear W21086650932018 @default.
- W2108665093 countsByYear W21086650932019 @default.
- W2108665093 countsByYear W21086650932020 @default.
- W2108665093 countsByYear W21086650932021 @default.