FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108670003> ?p ?o ?g. }

• W2108670003 endingPage "819" @default.
• W2108670003 startingPage "812" @default.
• W2108670003 abstract "Topotecan hydrochloride (TPT) has potential for the treatment of ovarian cancer, but the activity of TPT tends to decrease due to the ring-opening at physiological pH. In this study, we proposed to incorporate TPT liposomes into injectable thermosensitive in situ hydrogel, consisting of chitosan (CS) and β-glycerophosphate (β-GP), for sustained release and preservation of active lactone form of TPT. The rheology studies were carried out to investigate the sol–gel temperature, flow behavior and viscosity of these CS/β-GP systems. The optimized formulation exhibited sol–gel transition at 40.2 ± 0.4 °C, with pseudoplastic flow behavior. The drug release rate of TPT liposomes loaded CS/β-GP hydrogel in phosphate buffer saline (pH = 7.4) was found to be slowed down, and the lactone fraction of TPT in the hydrogel matrix was maintaining 40% after 50 h. In addition, the antitumor efficacy in Kunming mice bearing Hepatoma-22 tumor, after intratumoral injection of TPT liposomes loaded CS/β-GP hydrogel, was higher than that of TPT in saline and TPT in CS/β-GP hydrogel. Those results demonstrated that TPT liposomes loaded CS/β-GP hydrogel could become a potential formulation for improving the antitumor efficacy of TPT and suggested an important technology platform for intratumoral administration of derivative of camptothecin-family drugs." @default.
• W2108670003 created "2016-06-24" @default.
• W2108670003 creator A5007107060 @default.
• W2108670003 creator A5007828280 @default.
• W2108670003 creator A5020892027 @default.
• W2108670003 creator A5060312536 @default.
• W2108670003 creator A5067138179 @default.
• W2108670003 creator A5068161588 @default.
• W2108670003 creator A5077323251 @default.
• W2108670003 date "2014-06-09" @default.
• W2108670003 modified "2023-10-09" @default.
• W2108670003 title "Topotecan hydrochloride liposomes incorporated into thermosensitive hydrogel for sustained and efficient<i>in situ</i>therapy of H22 tumor in Kunming mice" @default.
• W2108670003 cites W1964766613 @default.
• W2108670003 cites W1965552267 @default.
• W2108670003 cites W1970511437 @default.
• W2108670003 cites W1973189310 @default.
• W2108670003 cites W1975616471 @default.
• W2108670003 cites W1977952516 @default.
• W2108670003 cites W1978500958 @default.
• W2108670003 cites W1981862878 @default.
• W2108670003 cites W1989989015 @default.
• W2108670003 cites W1990128204 @default.
• W2108670003 cites W1992374132 @default.
• W2108670003 cites W1994467229 @default.
• W2108670003 cites W1995175553 @default.
• W2108670003 cites W1997353385 @default.
• W2108670003 cites W2005790017 @default.
• W2108670003 cites W2007945345 @default.
• W2108670003 cites W2009999352 @default.
• W2108670003 cites W2012041550 @default.
• W2108670003 cites W2013460370 @default.
• W2108670003 cites W2018185888 @default.
• W2108670003 cites W2018443700 @default.
• W2108670003 cites W2033748094 @default.
• W2108670003 cites W2046351547 @default.
• W2108670003 cites W2050981032 @default.
• W2108670003 cites W2052057182 @default.
• W2108670003 cites W2056168675 @default.
• W2108670003 cites W2060493851 @default.
• W2108670003 cites W2062804635 @default.
• W2108670003 cites W2064630053 @default.
• W2108670003 cites W2065307591 @default.
• W2108670003 cites W2067983816 @default.
• W2108670003 cites W2078694420 @default.
• W2108670003 cites W2079407952 @default.
• W2108670003 cites W2086179083 @default.
• W2108670003 cites W2098904191 @default.
• W2108670003 cites W2101166734 @default.
• W2108670003 cites W2142634248 @default.
• W2108670003 cites W2146274229 @default.
• W2108670003 cites W2165948908 @default.
• W2108670003 cites W2322703639 @default.
• W2108670003 doi "https://doi.org/10.3109/10837450.2014.926918" @default.
• W2108670003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24909735" @default.
• W2108670003 hasPublicationYear "2014" @default.
• W2108670003 type Work @default.
• W2108670003 sameAs 2108670003 @default.
• W2108670003 citedByCount "15" @default.
• W2108670003 countsByYear W21086700032015 @default.
• W2108670003 countsByYear W21086700032016 @default.
• W2108670003 countsByYear W21086700032017 @default.
• W2108670003 countsByYear W21086700032018 @default.
• W2108670003 countsByYear W21086700032019 @default.
• W2108670003 countsByYear W21086700032020 @default.
• W2108670003 countsByYear W21086700032021 @default.
• W2108670003 countsByYear W21086700032022 @default.
• W2108670003 crossrefType "journal-article" @default.
• W2108670003 hasAuthorship W2108670003A5007107060 @default.
• W2108670003 hasAuthorship W2108670003A5007828280 @default.
• W2108670003 hasAuthorship W2108670003A5020892027 @default.
• W2108670003 hasAuthorship W2108670003A5060312536 @default.
• W2108670003 hasAuthorship W2108670003A5067138179 @default.
• W2108670003 hasAuthorship W2108670003A5068161588 @default.
• W2108670003 hasAuthorship W2108670003A5077323251 @default.
• W2108670003 hasConcept C141071460 @default.
• W2108670003 hasConcept C185154212 @default.
• W2108670003 hasConcept C185592680 @default.
• W2108670003 hasConcept C2776694085 @default.
• W2108670003 hasConcept C2779682216 @default.
• W2108670003 hasConcept C2781209748 @default.
• W2108670003 hasConcept C43617362 @default.
• W2108670003 hasConcept C55493867 @default.
• W2108670003 hasConcept C71924100 @default.
• W2108670003 hasConcept C98274493 @default.
• W2108670003 hasConceptScore W2108670003C141071460 @default.
• W2108670003 hasConceptScore W2108670003C185154212 @default.
• W2108670003 hasConceptScore W2108670003C185592680 @default.
• W2108670003 hasConceptScore W2108670003C2776694085 @default.
• W2108670003 hasConceptScore W2108670003C2779682216 @default.
• W2108670003 hasConceptScore W2108670003C2781209748 @default.
• W2108670003 hasConceptScore W2108670003C43617362 @default.
• W2108670003 hasConceptScore W2108670003C55493867 @default.
• W2108670003 hasConceptScore W2108670003C71924100 @default.
• W2108670003 hasConceptScore W2108670003C98274493 @default.
• W2108670003 hasIssue "7" @default.
• W2108670003 hasLocation W21086700031 @default.
• W2108670003 hasLocation W21086700032 @default.
• W2108670003 hasOpenAccess W2108670003 @default.

• next