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- W2108671666 abstract "Humoral immunity to viruses and encapsulated bacteria is comprised of T cell–independent type 2 (TI-2) antibody responses that are characterized by rapid antibody production by marginal zone and B1 B cells. We demonstrate that toll-like receptor (TLR) ligands influence the TI-2 antibody response not only by enhancing the overall magnitude but also by skewing this response to one that is dominated by IgG isotypes. Importantly, TLR ligands facilitate this response by inducing type I interferon (IFN), which in turn elicits rapid and significant amounts of antigen-specific IgG2c predominantly from FO (follicular) B cells. Furthermore, we show that although the IgG2c antibody response requires B cell–autonomous IFN-α receptor signaling, it is independent of B cell–intrinsic TLR signaling. Thus, innate signals have the capacity to enhance TI-2 antibody responses by promoting participation of FO B cells, which then elaborate effective IgG anti-pathogen antibodies." @default.
- W2108671666 created "2016-06-24" @default.
- W2108671666 creator A5020535485 @default.
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- W2108671666 creator A5037859093 @default.
- W2108671666 creator A5055691289 @default.
- W2108671666 creator A5055859027 @default.
- W2108671666 date "2010-06-21" @default.
- W2108671666 modified "2023-10-16" @default.
- W2108671666 title "Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response" @default.
- W2108671666 cites W1515043996 @default.
- W2108671666 cites W1542775986 @default.
- W2108671666 cites W1543092972 @default.
- W2108671666 cites W1561493617 @default.
- W2108671666 cites W1646309526 @default.
- W2108671666 cites W1757731638 @default.
- W2108671666 cites W1798949989 @default.
- W2108671666 cites W1820171215 @default.
- W2108671666 cites W1849784454 @default.
- W2108671666 cites W1853957385 @default.
- W2108671666 cites W1876204943 @default.
- W2108671666 cites W1895161339 @default.
- W2108671666 cites W1960918491 @default.
- W2108671666 cites W1964812677 @default.
- W2108671666 cites W1965286634 @default.
- W2108671666 cites W1979707388 @default.
- W2108671666 cites W1981069511 @default.
- W2108671666 cites W1982094117 @default.
- W2108671666 cites W1982474226 @default.
- W2108671666 cites W1984018777 @default.
- W2108671666 cites W1994094364 @default.
- W2108671666 cites W1994988800 @default.
- W2108671666 cites W1995045831 @default.
- W2108671666 cites W1996256410 @default.
- W2108671666 cites W1997489674 @default.
- W2108671666 cites W1997837324 @default.
- W2108671666 cites W2001988677 @default.
- W2108671666 cites W2004829503 @default.
- W2108671666 cites W2006735922 @default.
- W2108671666 cites W2006738527 @default.
- W2108671666 cites W2008073080 @default.
- W2108671666 cites W2009097329 @default.
- W2108671666 cites W2016821270 @default.
- W2108671666 cites W2022986271 @default.
- W2108671666 cites W2023216402 @default.
- W2108671666 cites W2025436792 @default.
- W2108671666 cites W2028575270 @default.
- W2108671666 cites W2028682232 @default.
- W2108671666 cites W2030698538 @default.
- W2108671666 cites W2031026925 @default.
- W2108671666 cites W2040112038 @default.
- W2108671666 cites W2045594979 @default.
- W2108671666 cites W2047882003 @default.
- W2108671666 cites W2048865828 @default.
- W2108671666 cites W2050772088 @default.
- W2108671666 cites W2054214000 @default.
- W2108671666 cites W2060290587 @default.
- W2108671666 cites W2061379835 @default.
- W2108671666 cites W2062715434 @default.
- W2108671666 cites W2063229662 @default.
- W2108671666 cites W2064421628 @default.
- W2108671666 cites W2065554630 @default.
- W2108671666 cites W2070570719 @default.
- W2108671666 cites W2075901113 @default.
- W2108671666 cites W2076361525 @default.
- W2108671666 cites W2078545286 @default.
- W2108671666 cites W2080082308 @default.
- W2108671666 cites W2085465802 @default.
- W2108671666 cites W2088593344 @default.
- W2108671666 cites W2091048996 @default.
- W2108671666 cites W2091835895 @default.
- W2108671666 cites W2095903025 @default.
- W2108671666 cites W2098854739 @default.
- W2108671666 cites W2100081088 @default.
- W2108671666 cites W2106203837 @default.
- W2108671666 cites W2110990893 @default.
- W2108671666 cites W2113295282 @default.
- W2108671666 cites W2114737175 @default.
- W2108671666 cites W2118481418 @default.
- W2108671666 cites W2118564683 @default.
- W2108671666 cites W2118991716 @default.
- W2108671666 cites W2119281067 @default.
- W2108671666 cites W2119864582 @default.
- W2108671666 cites W2122708834 @default.
- W2108671666 cites W2125566625 @default.
- W2108671666 cites W2127946778 @default.
- W2108671666 cites W2128623893 @default.
- W2108671666 cites W2132407227 @default.
- W2108671666 cites W2137157133 @default.
- W2108671666 cites W2137228866 @default.
- W2108671666 cites W2139605631 @default.
- W2108671666 cites W2142935638 @default.
- W2108671666 cites W2150232359 @default.
- W2108671666 cites W2156313733 @default.
- W2108671666 cites W2157296603 @default.
- W2108671666 cites W2158488893 @default.
- W2108671666 cites W2159491085 @default.