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• W2108672634 abstract "Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). The effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. The repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia." @default.
• W2108672634 created "2016-06-24" @default.
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• W2108672634 date "2008-02-16" @default.
• W2108672634 modified "2023-10-01" @default.
• W2108672634 title "Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?" @default.
• W2108672634 cites W1750132612 @default.
• W2108672634 cites W1897169513 @default.
• W2108672634 cites W1967233292 @default.
• W2108672634 cites W1969153406 @default.
• W2108672634 cites W1970348568 @default.
• W2108672634 cites W1972116107 @default.
• W2108672634 cites W1975187292 @default.
• W2108672634 cites W1980386735 @default.
• W2108672634 cites W1983291041 @default.
• W2108672634 cites W1983376112 @default.
• W2108672634 cites W1983542178 @default.
• W2108672634 cites W1990504544 @default.
• W2108672634 cites W1994806628 @default.
• W2108672634 cites W1996327177 @default.
• W2108672634 cites W1996814400 @default.
• W2108672634 cites W1997597038 @default.
• W2108672634 cites W1997981873 @default.
• W2108672634 cites W1998802214 @default.
• W2108672634 cites W1999845971 @default.
• W2108672634 cites W2000875378 @default.
• W2108672634 cites W2005756201 @default.
• W2108672634 cites W2009735254 @default.
• W2108672634 cites W2013336473 @default.
• W2108672634 cites W2013518271 @default.
• W2108672634 cites W2016601383 @default.
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• W2108672634 cites W2024647991 @default.
• W2108672634 cites W2024904747 @default.
• W2108672634 cites W2029037648 @default.
• W2108672634 cites W2030059527 @default.
• W2108672634 cites W2030915553 @default.
• W2108672634 cites W2039414366 @default.
• W2108672634 cites W2044982304 @default.
• W2108672634 cites W2047067656 @default.
• W2108672634 cites W2048079797 @default.
• W2108672634 cites W2052781981 @default.
• W2108672634 cites W2056093113 @default.
• W2108672634 cites W2058266245 @default.
• W2108672634 cites W2058734537 @default.
• W2108672634 cites W2061163047 @default.
• W2108672634 cites W2061899888 @default.
• W2108672634 cites W2064307164 @default.
• W2108672634 cites W2065600355 @default.
• W2108672634 cites W2080714711 @default.
• W2108672634 cites W2083609977 @default.
• W2108672634 cites W2090623565 @default.
• W2108672634 cites W2092204712 @default.
• W2108672634 cites W2092681518 @default.
• W2108672634 cites W2094244708 @default.
• W2108672634 cites W2094311708 @default.
• W2108672634 cites W2101700972 @default.
• W2108672634 cites W2137483563 @default.
• W2108672634 cites W2138985942 @default.
• W2108672634 cites W2145289471 @default.
• W2108672634 cites W2147782024 @default.
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• W2108672634 cites W2151797981 @default.
• W2108672634 cites W2154404325 @default.
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• W2108672634 cites W2158553737 @default.
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• W2108672634 cites W4213003651 @default.
• W2108672634 cites W4240049843 @default.
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• W2108672634 doi "https://doi.org/10.1093/schbul/sbn006" @default.
• W2108672634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2696367" @default.
• W2108672634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18281713" @default.
• W2108672634 hasPublicationYear "2008" @default.
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