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• W2108675610 abstract "Renal epithelial cells undergo apoptosis upon exposure to cadmium (Cd). Transcription factors, such as nuclear factor-kappa B (NF-κB), mediate the expression of a number of genes involved in apoptosis. The present study was designed to examine the involvement of this transcription factor in Cd-induced apoptosis. Rat kidney proximal tubular epithelial cells, NRK-52E, were incubated with up to 20μM CdCl2 in serum-free medium for 5 h followed by incubation in serum-containing medium (without Cd) for an additional 12 h. The cells accumulated 582 ± 19 ng Cd/mg protein after 5-h exposure to 20μM Cd. As a result of Cd exposure, the DNA-binding activity of the p65 subunit of NF-κB was decreased in a concentration- and time-dependent manner. The activity of tumor necrosis factor-α–induced inhibitor of kappa B (IκB) kinase α was also inhibited by Cd. In addition, the phosphorylation of IκB-α and NF-κB p65, as well as the levels of NF-κB target gene products, cIAP-1 and cIAP-2, were reduced. Pretreatment of the cells with the antioxidant U83836E or butylated hydroxytoluene preserved the DNA-binding activity and blocked the Cd-induced decease in IκB-α phosphorylation. Cd exposure caused the activation of caspase-3, -7, and -9 and DNA fragmentation. By flow cytometry, 14.6 and 30.5% apoptosis was detected at 6 and 12 h after stopping the Cd exposure. Overexpression of NF-κB p65 by transient transfection protected the cells from the Cd-induced apoptosis. Conversely, attenuation of NF-κB activity by pretreatment with SN50, an NF-κB nuclear translocation inhibitor, potentiated apoptosis. These results suggest that Cd-induced apoptosis involves suppression of NF-κB activity which may be mediated by oxidative stress." @default.
• W2108675610 created "2016-06-24" @default.
• W2108675610 creator A5066750627 @default.
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• W2108675610 date "2006-02-14" @default.
• W2108675610 modified "2023-10-02" @default.
• W2108675610 title "Cadmium-Induced Apoptosis in Rat Kidney Epithelial Cells Involves Decrease in Nuclear Factor-Kappa B Activity" @default.
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• W2108675610 doi "https://doi.org/10.1093/toxsci/kfj131" @default.
• W2108675610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16478757" @default.
• W2108675610 hasPublicationYear "2006" @default.
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