FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108676843> ?p ?o ?g. }

• W2108676843 endingPage "e71017" @default.
• W2108676843 startingPage "e71017" @default.
• W2108676843 abstract "Genetic disruption of myostatin or its related signaling is known to cause strong protection against diet-induced metabolic disorders. The translational value of these prior findings, however, is dependent on whether such metabolically favorable phenotype can be reproduced when myostatin blockade begins at an adult age. Here, we reported that AAV-mediated delivery of a myostatin pro-peptide D76A mutant in adult mice attenuates the development of hepatic steatosis and arteriosclerosis, two common diet-induced metabolic diseases. A single dose of AAV-D76A in adult Ldlr null mice resulted in sustained expression of myostatin pro-peptide in the liver. Compared to vehicle-treated mice, D76A-treated mice gained similar amount of lean and fat mass when fed a high fat diet. However, D76A-treated mice displayed significantly reduced aortic lesions and liver fat, in association with a reduction in hepatic expression of lipogenic genes and improvement in liver insulin sensitivity. This suggests that muscle and fat may not be the primary targets of treatment under our experimental condition. In support to this argument, we show that myostatin directly up-regulated lipogenic genes and increased fat accumulation in cultured liver cells. We also show that both myostatin and its receptor were abundantly expressed in mouse aorta. Cultured aortic endothelial cells responded to myostatin with a reduction in eNOS phosphorylation and an increase in ICAM-1 and VCAM-1 expression.AAV-mediated expression of myostatin pro-peptide D76A mutant in adult Ldlr null mice sustained metabolic protection without remarkable impacts on body lean and fat mass. Further investigations are needed to determine whether direct impact of myostatin on liver and aortic endothelium may contribute to the related metabolic phenotypes." @default.
• W2108676843 created "2016-06-24" @default.
• W2108676843 creator A5071176339 @default.
• W2108676843 creator A5076909940 @default.
• W2108676843 creator A5081996518 @default.
• W2108676843 date "2013-08-01" @default.
• W2108676843 modified "2023-09-26" @default.
• W2108676843 title "AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis" @default.
• W2108676843 cites W1585509587 @default.
• W2108676843 cites W1768478110 @default.
• W2108676843 cites W1963621782 @default.
• W2108676843 cites W1968316822 @default.
• W2108676843 cites W1974550903 @default.
• W2108676843 cites W1976508599 @default.
• W2108676843 cites W1976884806 @default.
• W2108676843 cites W1980333534 @default.
• W2108676843 cites W1980579696 @default.
• W2108676843 cites W1982626985 @default.
• W2108676843 cites W1982715073 @default.
• W2108676843 cites W1983688182 @default.
• W2108676843 cites W1986156265 @default.
• W2108676843 cites W1992304595 @default.
• W2108676843 cites W1998948324 @default.
• W2108676843 cites W2000440477 @default.
• W2108676843 cites W2006256602 @default.
• W2108676843 cites W2008289270 @default.
• W2108676843 cites W2008438711 @default.
• W2108676843 cites W2021263701 @default.
• W2108676843 cites W2021870008 @default.
• W2108676843 cites W2022019215 @default.
• W2108676843 cites W2023806016 @default.
• W2108676843 cites W2025372537 @default.
• W2108676843 cites W2028966038 @default.
• W2108676843 cites W2030036012 @default.
• W2108676843 cites W2042031605 @default.
• W2108676843 cites W2047284298 @default.
• W2108676843 cites W2048930761 @default.
• W2108676843 cites W2049379194 @default.
• W2108676843 cites W2052677026 @default.
• W2108676843 cites W2053079324 @default.
• W2108676843 cites W2057293159 @default.
• W2108676843 cites W2063355128 @default.
• W2108676843 cites W2071807728 @default.
• W2108676843 cites W2074127387 @default.
• W2108676843 cites W2082794356 @default.
• W2108676843 cites W2086501724 @default.
• W2108676843 cites W2087956226 @default.
• W2108676843 cites W2101327974 @default.
• W2108676843 cites W2106719297 @default.
• W2108676843 cites W2109377449 @default.
• W2108676843 cites W2111736445 @default.
• W2108676843 cites W2116711650 @default.
• W2108676843 cites W2124464501 @default.
• W2108676843 cites W2132813206 @default.
• W2108676843 cites W2133828201 @default.
• W2108676843 cites W2149968000 @default.
• W2108676843 cites W2149993139 @default.
• W2108676843 cites W2157467578 @default.
• W2108676843 cites W2160199212 @default.
• W2108676843 cites W2165995731 @default.
• W2108676843 cites W2166947475 @default.
• W2108676843 cites W2172002988 @default.
• W2108676843 cites W2290374156 @default.
• W2108676843 doi "https://doi.org/10.1371/journal.pone.0071017" @default.
• W2108676843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731267" @default.
• W2108676843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23936482" @default.
• W2108676843 hasPublicationYear "2013" @default.
• W2108676843 type Work @default.
• W2108676843 sameAs 2108676843 @default.
• W2108676843 citedByCount "15" @default.
• W2108676843 countsByYear W21086768432014 @default.
• W2108676843 countsByYear W21086768432017 @default.
• W2108676843 countsByYear W21086768432019 @default.
• W2108676843 countsByYear W21086768432021 @default.
• W2108676843 crossrefType "journal-article" @default.
• W2108676843 hasAuthorship W2108676843A5071176339 @default.
• W2108676843 hasAuthorship W2108676843A5076909940 @default.
• W2108676843 hasAuthorship W2108676843A5081996518 @default.
• W2108676843 hasBestOaLocation W21086768431 @default.
• W2108676843 hasConcept C126322002 @default.
• W2108676843 hasConcept C134018914 @default.
• W2108676843 hasConcept C167414201 @default.
• W2108676843 hasConcept C170493617 @default.
• W2108676843 hasConcept C2776175330 @default.
• W2108676843 hasConcept C2776393769 @default.
• W2108676843 hasConcept C2777488582 @default.
• W2108676843 hasConcept C2778163477 @default.
• W2108676843 hasConcept C2778772119 @default.
• W2108676843 hasConcept C2779134260 @default.
• W2108676843 hasConcept C2780072125 @default.
• W2108676843 hasConcept C43554185 @default.
• W2108676843 hasConcept C71924100 @default.
• W2108676843 hasConcept C86803240 @default.
• W2108676843 hasConceptScore W2108676843C126322002 @default.
• W2108676843 hasConceptScore W2108676843C134018914 @default.
• W2108676843 hasConceptScore W2108676843C167414201 @default.
• W2108676843 hasConceptScore W2108676843C170493617 @default.
• W2108676843 hasConceptScore W2108676843C2776175330 @default.

• next