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- W2108681389 abstract "Cilia and flagella play multiple essential roles in animal development and cell physiology. Defective cilium assembly or motility represents the etiological basis for a growing number of human diseases. Therefore, how cilia and flagella assemble and the processes that drive motility are essential for understanding these diseases. Here we show that Drosophila Bld10, the ortholog of Chlamydomonas reinhardtii Bld10p and human Cep135, is a ubiquitous centriolar protein that also localizes to the spermatid basal body. Mutants that lack Bld10 assemble centrioles and form functional centrosomes, but centrioles and spermatid basal bodies are short in length. bld10 mutant flies are viable but male sterile, producing immotile sperm whose axonemes are deficient in the central pair of microtubules. These results show that Drosophila Bld10 is required for centriole and axoneme assembly to confer cilium motility." @default.
- W2108681389 created "2016-06-24" @default.
- W2108681389 creator A5061329267 @default.
- W2108681389 creator A5085690129 @default.
- W2108681389 date "2009-05-15" @default.
- W2108681389 modified "2023-10-16" @default.
- W2108681389 title "<i>Drosophila</i>Bld10 Is a Centriolar Protein That Regulates Centriole, Basal Body, and Motile Cilium Assembly" @default.
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- W2108681389 doi "https://doi.org/10.1091/mbc.e08-11-1115" @default.
- W2108681389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2682601" @default.
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- W2108681389 hasPublicationYear "2009" @default.
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