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• W2108685671 endingPage "18" @default.
• W2108685671 startingPage "9" @default.
• W2108685671 abstract "ABSTRACT Most human immunodeficiency virus (HIV) type 1 infections occur by the mucosal route. Thus, it is important to assess the immune responses to HIV in the vaginal, cervical, and rectal compartments. Here we quantitated the virus-specific CD8 + T-cell response and characterized the phenotype of lymphocytes in the genital tracts of naive macaques, macaques acutely or chronically infected with simian immunodeficiency virus SIV mac251 , and macaques chronically infected with chimeric simian/human immunodeficiency virus SHIV KU2. Vaginal biopsy samples or samples obtained at the time of euthanasia were used in this analysis. The percentage of Gag-specific, tetramer-positive T cells was as high as 13 to 14% of the CD3 + CD8 + T-cell population in the vaginal and cervical laminae propriae of both SIV mac251 and SHIV KU2 chronically infected macaques. In most cases, the frequency of this response in the cervicovaginal compartment far exceeded the frequency in the blood or the draining iliac lymph node. Vaginal laminae propriae of naive macaques contained 55 to 65% CD3 + CD8 + cells and 28 to 34% CD3 + CD4 + cells, while the majority of intraepithelial cells were CD8 + T cells (75 to 85%). For the same cells, the surface expression of CD62L was low whereas that of αEβ7 was high. No difference in the expression of CD45RA on CD8 + T cells was observed in the chronic stage of SIV mac251 infection. Although no decrease in the percentage of CD4 + cells in the genital tract was observed within the first 12 days of infection, by 6 weeks from SIV mac251 infection and thereafter the percentage of CD4 + T cells was decreased in the laminae propriae of the vagina and cervix. Expression of CD45RA did not differ in naive and acutely SIV mac251 infected macaques. Information on the quality and quantity of local immune responses may help in the design of vaccine strategies aimed at containing viral replication at the site of viral encounter." @default.
• W2108685671 created "2016-06-24" @default.
• W2108685671 creator A5034091192 @default.
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• W2108685671 date "2002-01-01" @default.
• W2108685671 modified "2023-09-30" @default.
• W2108685671 title "Cervicovaginal Lamina Propria Lymphocytes: Phenotypic Characterization and Their Importance in Cytotoxic T-Lymphocyte Responses to Simian Immunodeficiency Virus SIV_mac251" @default.
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• W2108685671 doi "https://doi.org/10.1128/jvi.76.1.9-18.2002" @default.
• W2108685671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/135704" @default.
• W2108685671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11739667" @default.
• W2108685671 hasPublicationYear "2002" @default.
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