FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108698265> ?p ?o ?g. }

• W2108698265 endingPage "718" @default.
• W2108698265 startingPage "701" @default.
• W2108698265 abstract "To investigate the role of epithelial-mesenchymal interaction on oxygen-induced lung injury, we used a coculture model with lung fibroblasts (FB) embedded between 2 layers of collagen gel with and without human tracheobronchial epithelial cells (HTBE), and studied the effect of hyperoxia on the directed migration of FB towards epithelial cells and proliferation of fetal lung FB. The expression of insulin-like growth factor (IGF)-I, -II, and -IIR mRNAs and proteins was studied in FB and HTBE cells cultured separately in 95% oxygen and 5% CO2 for 48 hours. There was a significant increase in directional migration of FB in coculture with epithelial cells when exposed to 95% oxygen and 5% CO2 (P = .04 compared to cocultures without oxygen exposure). Hyperoxia stimulated the proliferation of fibroblasts cocultured with HTBE cells (0.75 +/- 0.05 x 10(6) cells per well) as compared to control (0.47 +/- 0.03 x 10(6) cells per well; P = .01). This was inhibited by anti-IGF-I antibody (69 +/- 2% of hyperoxia alone; P = .002). Western blot showed a significant increase in IGF-I protein in epithelial cells (P = .02). IGF-I mRNA was increased in HTBE cells after hyperoxia (P = .003). In conclusion, HTBE cells modulate lung FB migration and proliferation in response to hyperoxia exposure. This is mediated in part by IGF-I produced by epithelial cells." @default.
• W2108698265 created "2016-06-24" @default.
• W2108698265 creator A5048656180 @default.
• W2108698265 creator A5055796232 @default.
• W2108698265 creator A5065802764 @default.
• W2108698265 date "1999-01-01" @default.
• W2108698265 modified "2023-09-26" @default.
• W2108698265 title "EPITHELIAL-MESENCHYMAL INTERACTION AND INSULIN-LIKE GROWTH FACTORS IN HYPEROXIC LUNG INJURY" @default.
• W2108698265 cites W1282498 @default.
• W2108698265 cites W1565526431 @default.
• W2108698265 cites W1791131480 @default.
• W2108698265 cites W1899680617 @default.
• W2108698265 cites W1938846285 @default.
• W2108698265 cites W1983284888 @default.
• W2108698265 cites W2020019854 @default.
• W2108698265 cites W2020170334 @default.
• W2108698265 cites W2025230591 @default.
• W2108698265 cites W2034331257 @default.
• W2108698265 cites W2047184080 @default.
• W2108698265 cites W2054569336 @default.
• W2108698265 cites W2056283427 @default.
• W2108698265 cites W2058604971 @default.
• W2108698265 cites W2065496745 @default.
• W2108698265 cites W2068554565 @default.
• W2108698265 cites W2071761708 @default.
• W2108698265 cites W2082668280 @default.
• W2108698265 cites W2083637184 @default.
• W2108698265 cites W2094113009 @default.
• W2108698265 cites W2104606637 @default.
• W2108698265 cites W2126803524 @default.
• W2108698265 cites W2127006469 @default.
• W2108698265 cites W2151170471 @default.
• W2108698265 cites W2409630338 @default.
• W2108698265 cites W2409968944 @default.
• W2108698265 cites W2594294830 @default.
• W2108698265 cites W2337429812 @default.
• W2108698265 doi "https://doi.org/10.1080/019021499270015" @default.
• W2108698265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10643566" @default.
• W2108698265 hasPublicationYear "1999" @default.
• W2108698265 type Work @default.
• W2108698265 sameAs 2108698265 @default.
• W2108698265 citedByCount "15" @default.
• W2108698265 countsByYear W21086982652012 @default.
• W2108698265 countsByYear W21086982652018 @default.
• W2108698265 countsByYear W21086982652020 @default.
• W2108698265 crossrefType "journal-article" @default.
• W2108698265 hasAuthorship W2108698265A5048656180 @default.
• W2108698265 hasAuthorship W2108698265A5055796232 @default.
• W2108698265 hasAuthorship W2108698265A5065802764 @default.
• W2108698265 hasConcept C104317684 @default.
• W2108698265 hasConcept C126322002 @default.
• W2108698265 hasConcept C134018914 @default.
• W2108698265 hasConcept C153911025 @default.
• W2108698265 hasConcept C16685009 @default.
• W2108698265 hasConcept C170493617 @default.
• W2108698265 hasConcept C185592680 @default.
• W2108698265 hasConcept C198826908 @default.
• W2108698265 hasConcept C2775960820 @default.
• W2108698265 hasConcept C2776415932 @default.
• W2108698265 hasConcept C2777714996 @default.
• W2108698265 hasConcept C2780672939 @default.
• W2108698265 hasConcept C2780689927 @default.
• W2108698265 hasConcept C55493867 @default.
• W2108698265 hasConcept C62112901 @default.
• W2108698265 hasConcept C71924100 @default.
• W2108698265 hasConcept C86803240 @default.
• W2108698265 hasConcept C95444343 @default.
• W2108698265 hasConceptScore W2108698265C104317684 @default.
• W2108698265 hasConceptScore W2108698265C126322002 @default.
• W2108698265 hasConceptScore W2108698265C134018914 @default.
• W2108698265 hasConceptScore W2108698265C153911025 @default.
• W2108698265 hasConceptScore W2108698265C16685009 @default.
• W2108698265 hasConceptScore W2108698265C170493617 @default.
• W2108698265 hasConceptScore W2108698265C185592680 @default.
• W2108698265 hasConceptScore W2108698265C198826908 @default.
• W2108698265 hasConceptScore W2108698265C2775960820 @default.
• W2108698265 hasConceptScore W2108698265C2776415932 @default.
• W2108698265 hasConceptScore W2108698265C2777714996 @default.
• W2108698265 hasConceptScore W2108698265C2780672939 @default.
• W2108698265 hasConceptScore W2108698265C2780689927 @default.
• W2108698265 hasConceptScore W2108698265C55493867 @default.
• W2108698265 hasConceptScore W2108698265C62112901 @default.
• W2108698265 hasConceptScore W2108698265C71924100 @default.
• W2108698265 hasConceptScore W2108698265C86803240 @default.
• W2108698265 hasConceptScore W2108698265C95444343 @default.
• W2108698265 hasIssue "8" @default.
• W2108698265 hasLocation W21086982651 @default.
• W2108698265 hasLocation W21086982652 @default.
• W2108698265 hasOpenAccess W2108698265 @default.
• W2108698265 hasPrimaryLocation W21086982651 @default.
• W2108698265 hasRelatedWork W1995752015 @default.
• W2108698265 hasRelatedWork W2341115913 @default.
• W2108698265 hasRelatedWork W2364551404 @default.
• W2108698265 hasRelatedWork W2366106301 @default.
• W2108698265 hasRelatedWork W2367071538 @default.
• W2108698265 hasRelatedWork W2386983130 @default.
• W2108698265 hasRelatedWork W2388010920 @default.
• W2108698265 hasRelatedWork W2390582396 @default.

• next