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- W2108698544 abstract "The determination of clinical significance is a process of comparing therapeutic results to a subjectively derived set of criteria. Different persons often reach different decisions when presented with the same evidence regarding the benefits and harms associated with a treatment. Traditionally, clinical significance has been a yes-or-no decision. The purpose of this article is to add more structure to the process, by transforming a yes-or-no decision to a categorical decision. We propose to define 4 levels of clinical significance on the basis of the nature of the anticipated benefits (tangible versus intangible) and the likelihood for obtaining the benefit (large versus small). Rating the clinical significance of a treatment on a categorical basis may provide a useful tool to efficiently communicate the degree of belief in the benefit of a therapy." @default.
- W2108698544 created "2016-06-24" @default.
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- W2108698544 date "2004-03-01" @default.
- W2108698544 modified "2023-09-26" @default.
- W2108698544 title "Levels of Clinical Significance" @default.
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- W2108698544 doi "https://doi.org/10.1016/j.jebdp.2004.02.012" @default.
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