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• W2108701319 abstract "Background: Persons with cystic fibrosis (CF) and pancreatic insufficiency (PI) are at risk of vitamin A deficiency because of steatorrhea, despite pancreatic enzyme replacement. Long-standing vitamin A supplementation may increase the risk of vitamin A toxicity. Objective: The aim was to describe the vitamin A intake and serum retinol concentrations of preadolescent children with CF, PI, and mild-to-moderate pulmonary disease, who were cared for under current practice recommendations. Design: This cross-sectional study evaluated children aged 8.0–11.9 y with CF and PI from 13 US CF centers. Dietary and supplemental vitamin A intakes were compared with the Dietary Reference Intakes (DRIs) for healthy children, CF recommendations, and data from the National Health and Nutrition Examination Survey (NHANES), 1999–2000. Serum retinol concentrations were compared with NHANES data. Results: The 73 subjects with CF had a dietary vitamin A intake of 816 ± 336 μg retinol activity equivalents (165 ± 69% of the recommended dietary allowance), which was similar to the NHANES value. The supplement intake provided 2234 ± 1574 μg retinol activity equivalents/d and exceeded recommendations in 21% of the subjects with CF. Total preformed retinol intake exceeded the DRI tolerable upper intake level in 78% of the subjects with CF. The serum retinol concentration was 52 ± 13 μg/dL (range: 26–98 μg/dL), which was significantly higher than the NHANES value (37 ± 10 μg/dL; range: 17–63 μg/dL; P < 0.001). Conclusion: Although supplementation helps to prevent vitamin A deficiency in children with CF and PI, their high vitamin A intakes and serum retinol concentrations suggest that usual care may result in excessive vitamin A intake and possible toxicity that would increase the risk of CF-associated liver and bone complications." @default.
• W2108701319 created "2016-06-24" @default.
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• W2108701319 date "2006-07-01" @default.
• W2108701319 modified "2023-10-14" @default.
• W2108701319 title "Elevated vitamin A intake and serum retinol in preadolescent children with cystic fibrosis" @default.
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• W2108701319 doi "https://doi.org/10.1093/ajcn/84.1.174" @default.
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