Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108709819> ?p ?o ?g. }
- W2108709819 endingPage "1440" @default.
- W2108709819 startingPage "1433" @default.
- W2108709819 abstract "Previous studies of the elderly immune response to TI-2 antigens failed to correlate specific antibody levels with function and to compare responses with those of young adults. Neisseria meningitidis serogroup C capsular polysaccharide (MCPS) was used as a model TI-2 antigen. Anti-MCPS antibody levels were determined in elderly individuals and correlated with bactericidal activity. The anti-MCPS response in most persons was characterized by predominant IgG usage, with IgG2 > IgG1. No light chain or IgA subclass predominated, but some responses showed a particular chain type. Bactericidal activity correlated best with IgG2 levels. Elderly subjects had lower anti-MCPS responses than the young adults did in all chain-specific anti-MCPS levels, and levels declined more rapidly. Bactericidal activity following immunization was significantly lower in the elderly persons. These results suggest the anti-MCPS antibody repertoire in the elderly is likely maintained, and the lower level of function is related to the lower antibody levels." @default.
- W2108709819 created "2016-06-24" @default.
- W2108709819 creator A5029181889 @default.
- W2108709819 creator A5082857268 @default.
- W2108709819 creator A5091840440 @default.
- W2108709819 date "1999-06-01" @default.
- W2108709819 modified "2023-09-27" @default.
- W2108709819 title "Elderly Immune Response to a TI‐2 Antigen: Heavy and Light Chain Use and Bactericidal Activity to<i>Neisseria meningitidis</i>Serogroup C Polysaccharide" @default.
- W2108709819 cites W1495072736 @default.
- W2108709819 cites W1535968258 @default.
- W2108709819 cites W1546439114 @default.
- W2108709819 cites W1551917767 @default.
- W2108709819 cites W1577104641 @default.
- W2108709819 cites W1578803305 @default.
- W2108709819 cites W1607182675 @default.
- W2108709819 cites W1680951199 @default.
- W2108709819 cites W1788888927 @default.
- W2108709819 cites W1912692997 @default.
- W2108709819 cites W1934670278 @default.
- W2108709819 cites W1975408746 @default.
- W2108709819 cites W1975608671 @default.
- W2108709819 cites W1995344823 @default.
- W2108709819 cites W1997230014 @default.
- W2108709819 cites W2001995433 @default.
- W2108709819 cites W2007486158 @default.
- W2108709819 cites W2011172502 @default.
- W2108709819 cites W2013048333 @default.
- W2108709819 cites W2013333172 @default.
- W2108709819 cites W2016296292 @default.
- W2108709819 cites W2023014119 @default.
- W2108709819 cites W2028848475 @default.
- W2108709819 cites W2033605848 @default.
- W2108709819 cites W2033645271 @default.
- W2108709819 cites W2033939525 @default.
- W2108709819 cites W2043372168 @default.
- W2108709819 cites W2043464691 @default.
- W2108709819 cites W2046267384 @default.
- W2108709819 cites W2047962308 @default.
- W2108709819 cites W2062504889 @default.
- W2108709819 cites W2071832826 @default.
- W2108709819 cites W2071882418 @default.
- W2108709819 cites W2075491595 @default.
- W2108709819 cites W2096869346 @default.
- W2108709819 cites W2103752453 @default.
- W2108709819 cites W2106643164 @default.
- W2108709819 cites W2110801981 @default.
- W2108709819 cites W2115350923 @default.
- W2108709819 cites W2118025642 @default.
- W2108709819 cites W2123951868 @default.
- W2108709819 cites W2132181699 @default.
- W2108709819 cites W2133380168 @default.
- W2108709819 cites W2134778321 @default.
- W2108709819 cites W2147633732 @default.
- W2108709819 cites W2149177957 @default.
- W2108709819 cites W2155610175 @default.
- W2108709819 cites W2156638216 @default.
- W2108709819 cites W2159670176 @default.
- W2108709819 cites W2162072688 @default.
- W2108709819 cites W2170761079 @default.
- W2108709819 cites W2223662840 @default.
- W2108709819 cites W2268438199 @default.
- W2108709819 cites W2282144476 @default.
- W2108709819 cites W2285927317 @default.
- W2108709819 cites W2327132684 @default.
- W2108709819 cites W2342228817 @default.
- W2108709819 cites W2396106948 @default.
- W2108709819 cites W2397415531 @default.
- W2108709819 cites W2402075445 @default.
- W2108709819 cites W2419925089 @default.
- W2108709819 cites W2906134710 @default.
- W2108709819 cites W2322457129 @default.
- W2108709819 doi "https://doi.org/10.1086/314750" @default.
- W2108709819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10228065" @default.
- W2108709819 hasPublicationYear "1999" @default.
- W2108709819 type Work @default.
- W2108709819 sameAs 2108709819 @default.
- W2108709819 citedByCount "16" @default.
- W2108709819 countsByYear W21087098192012 @default.
- W2108709819 countsByYear W21087098192015 @default.
- W2108709819 countsByYear W21087098192017 @default.
- W2108709819 countsByYear W21087098192019 @default.
- W2108709819 crossrefType "journal-article" @default.
- W2108709819 hasAuthorship W2108709819A5029181889 @default.
- W2108709819 hasAuthorship W2108709819A5082857268 @default.
- W2108709819 hasAuthorship W2108709819A5091840440 @default.
- W2108709819 hasBestOaLocation W21087098191 @default.
- W2108709819 hasConcept C147483822 @default.
- W2108709819 hasConcept C159654299 @default.
- W2108709819 hasConcept C203014093 @default.
- W2108709819 hasConcept C2778458888 @default.
- W2108709819 hasConcept C2779102806 @default.
- W2108709819 hasConcept C2780801004 @default.
- W2108709819 hasConcept C2780898057 @default.
- W2108709819 hasConcept C3018913218 @default.
- W2108709819 hasConcept C523546767 @default.
- W2108709819 hasConcept C54355233 @default.
- W2108709819 hasConcept C71924100 @default.
- W2108709819 hasConcept C86803240 @default.