FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108732005> ?p ?o ?g. }

• W2108732005 endingPage "415" @default.
• W2108732005 startingPage "406" @default.
• W2108732005 abstract "Heat shock protein 90 (HSP90) binds and stabilizes numerous proteins and kinases essential for myeloma cell survival and proliferation. We and others have recently demonstrated that inhibition of HSP90 by small molecular mass inhibitors induces cell death in multiple myeloma (MM). However, some of the HSP90 inhibitors involved in early clinical trials have shown limited antitumor activity and unfavorable toxicity profiles. Here, we analyzed the effects of the novel, orally bioavailable HSP90 inhibitor NVP-HSP990 on MM cell proliferation and survival. The inhibitor led to a significant reduction in myeloma cell viability and induced G2 cell cycle arrest, degradation of caspase-8 and caspase-3, and induction of apoptosis. Inhibition of the HSP90 ATPase activity was accompanied by the degradation of MM phospho-Akt and phospho-ERK1/2 and upregulation of Hsp70. Exposure of MM cells to a combination of NVP-HSP990 and either melphalan or histone deacetylase (HDAC) inhibitors caused synergistic inhibition of viability, increased induction of apoptosis, and was able to overcome the primary resistance of the cell line RPMI-8226 to HSP90 inhibition. Combined incubation with melphalan and NVP-HSP990 led to synergistically increased cleavage of caspase-2, caspase-9, and caspase-3. These data demonstrate promising activity for NVP-HSP990 as single agent or combination treatment in MM and provide a rationale for clinical trials." @default.
• W2108732005 created "2016-06-24" @default.
• W2108732005 creator A5022668758 @default.
• W2108732005 creator A5029953314 @default.
• W2108732005 creator A5030476746 @default.
• W2108732005 creator A5031361683 @default.
• W2108732005 creator A5047187056 @default.
• W2108732005 creator A5060471961 @default.
• W2108732005 creator A5067763436 @default.
• W2108732005 creator A5073477610 @default.
• W2108732005 creator A5085981984 @default.
• W2108732005 creator A5088783809 @default.
• W2108732005 date "2012-03-21" @default.
• W2108732005 modified "2023-10-17" @default.
• W2108732005 title "The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases" @default.
• W2108732005 cites W1944559787 @default.
• W2108732005 cites W1964328292 @default.
• W2108732005 cites W1971275552 @default.
• W2108732005 cites W1972705137 @default.
• W2108732005 cites W1976980728 @default.
• W2108732005 cites W1991522181 @default.
• W2108732005 cites W2001742494 @default.
• W2108732005 cites W2002044132 @default.
• W2108732005 cites W2009584325 @default.
• W2108732005 cites W2015880063 @default.
• W2108732005 cites W2021534705 @default.
• W2108732005 cites W2022531767 @default.
• W2108732005 cites W2031157863 @default.
• W2108732005 cites W2032025341 @default.
• W2108732005 cites W2064704783 @default.
• W2108732005 cites W2066800926 @default.
• W2108732005 cites W2071434932 @default.
• W2108732005 cites W2077945404 @default.
• W2108732005 cites W2085488129 @default.
• W2108732005 cites W2092058250 @default.
• W2108732005 cites W2093048712 @default.
• W2108732005 cites W2096207943 @default.
• W2108732005 cites W2097347894 @default.
• W2108732005 cites W2119260905 @default.
• W2108732005 cites W2123214410 @default.
• W2108732005 cites W2126437686 @default.
• W2108732005 cites W2131384028 @default.
• W2108732005 cites W2148152967 @default.
• W2108732005 cites W2158341833 @default.
• W2108732005 cites W2158797202 @default.
• W2108732005 cites W2162468902 @default.
• W2108732005 doi "https://doi.org/10.1111/j.1600-0609.2012.01764.x" @default.
• W2108732005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22309072" @default.
• W2108732005 hasPublicationYear "2012" @default.
• W2108732005 type Work @default.
• W2108732005 sameAs 2108732005 @default.
• W2108732005 citedByCount "23" @default.
• W2108732005 countsByYear W21087320052013 @default.
• W2108732005 countsByYear W21087320052014 @default.
• W2108732005 countsByYear W21087320052015 @default.
• W2108732005 countsByYear W21087320052017 @default.
• W2108732005 countsByYear W21087320052018 @default.
• W2108732005 countsByYear W21087320052019 @default.
• W2108732005 countsByYear W21087320052020 @default.
• W2108732005 countsByYear W21087320052021 @default.
• W2108732005 countsByYear W21087320052022 @default.
• W2108732005 countsByYear W21087320052023 @default.
• W2108732005 crossrefType "journal-article" @default.
• W2108732005 hasAuthorship W2108732005A5022668758 @default.
• W2108732005 hasAuthorship W2108732005A5029953314 @default.
• W2108732005 hasAuthorship W2108732005A5030476746 @default.
• W2108732005 hasAuthorship W2108732005A5031361683 @default.
• W2108732005 hasAuthorship W2108732005A5047187056 @default.
• W2108732005 hasAuthorship W2108732005A5060471961 @default.
• W2108732005 hasAuthorship W2108732005A5067763436 @default.
• W2108732005 hasAuthorship W2108732005A5073477610 @default.
• W2108732005 hasAuthorship W2108732005A5085981984 @default.
• W2108732005 hasAuthorship W2108732005A5088783809 @default.
• W2108732005 hasConcept C104317684 @default.
• W2108732005 hasConcept C105696609 @default.
• W2108732005 hasConcept C185592680 @default.
• W2108732005 hasConcept C190283241 @default.
• W2108732005 hasConcept C203014093 @default.
• W2108732005 hasConcept C205260736 @default.
• W2108732005 hasConcept C2775932338 @default.
• W2108732005 hasConcept C2776364478 @default.
• W2108732005 hasConcept C2777478702 @default.
• W2108732005 hasConcept C2777560012 @default.
• W2108732005 hasConcept C29537977 @default.
• W2108732005 hasConcept C31573885 @default.
• W2108732005 hasConcept C502942594 @default.
• W2108732005 hasConcept C53227056 @default.
• W2108732005 hasConcept C55493867 @default.
• W2108732005 hasConcept C62112901 @default.
• W2108732005 hasConcept C86803240 @default.
• W2108732005 hasConcept C98274493 @default.
• W2108732005 hasConcept C98424977 @default.
• W2108732005 hasConceptScore W2108732005C104317684 @default.
• W2108732005 hasConceptScore W2108732005C105696609 @default.
• W2108732005 hasConceptScore W2108732005C185592680 @default.
• W2108732005 hasConceptScore W2108732005C190283241 @default.
• W2108732005 hasConceptScore W2108732005C203014093 @default.
• W2108732005 hasConceptScore W2108732005C205260736 @default.

• next