FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108736057> ?p ?o ?g. }

• W2108736057 endingPage "2948" @default.
• W2108736057 startingPage "2939" @default.
• W2108736057 abstract "Abstract Purpose: BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family of proteins. This study was designed to investigate the mechanism of BLID-induced apoptosis and to assess the significance of BLID expression in breast cancer. Experimental Design: The interaction between BLID and Bcl-XL was examined using in vitro transcription/translation, coimmunoprecipitation, and immunoflourescence assays. The relationship between BLID mRNA expression and pathologic measures in breast cancer specimens (n = 55) was examined using the publicly available ONCOMINE microarray database. Immunohistochemistry was done using formalin-fixed, paraffin-embedded sections of 148 cases of invasive ductal breast carcinomas (IDC) and 58 cases of invasive lobular breast carcinomas, and breast tissue microarrays representing additional 437 cases (&gt;85% IDC) with associated clinicopathologic database and long-term clinical follow-up (median 7 years). Results: BLID was found to interact with Bcl-XL, and the binding was enhanced in cancer cells exposed to doxorubicin or cisplatin. Exogenous expression of BLID correlated with activation of Bax and an increase in cytosolic cytochrome c. BLID mRNA expression was significantly reduced in grade 3 relative to grade 1 and 2 breast cancer (P = 0.023). Cytoplasmic BLID immunoreactivity was absent in IDC compared with invasive lobular breast carcinoma (P &lt; 0.001). Lack of BLID expression was associated with younger age (median 40 years), African American ethnicity, tumor size, and triple-negative breast cancer (estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative; all P &lt; 0.005). Significant correlations were observed between BLID negativity and declines in overall, cause-specific, and local relapse-free survival (all P &lt; 0.03). Multivariate analysis indicated that BLID is an independent prognostic factor of distant metastasis-free survival (hazard ratio, 0.302; 95% confidence interval, 0.160-0.570, P = 0.0002). Conclusion: BLID is a new binding partner of Bcl-XL and a significant prognostic factor in breast cancer. Clin Cancer Res; 16(11); 2939–48. ©2010 AACR." @default.
• W2108736057 created "2016-06-24" @default.
• W2108736057 creator A5001649072 @default.
• W2108736057 creator A5010153046 @default.
• W2108736057 creator A5017396692 @default.
• W2108736057 creator A5019504883 @default.
• W2108736057 creator A5023487576 @default.
• W2108736057 creator A5030299515 @default.
• W2108736057 creator A5032933031 @default.
• W2108736057 creator A5032949456 @default.
• W2108736057 creator A5048976108 @default.
• W2108736057 creator A5063899863 @default.
• W2108736057 creator A5088559019 @default.
• W2108736057 creator A5090245498 @default.
• W2108736057 date "2010-05-31" @default.
• W2108736057 modified "2023-09-26" @default.
• W2108736057 title "The Proapoptotic Molecule BLID Interacts with Bcl-XL and Its Downregulation in Breast Cancer Correlates with Poor Disease-Free and Overall Survival" @default.
• W2108736057 cites W1271389891 @default.
• W2108736057 cites W1488998215 @default.
• W2108736057 cites W1965734230 @default.
• W2108736057 cites W1975607775 @default.
• W2108736057 cites W1977918192 @default.
• W2108736057 cites W1986383075 @default.
• W2108736057 cites W1994847588 @default.
• W2108736057 cites W1996724130 @default.
• W2108736057 cites W2010494439 @default.
• W2108736057 cites W2010690528 @default.
• W2108736057 cites W2036397716 @default.
• W2108736057 cites W2041115282 @default.
• W2108736057 cites W2056418403 @default.
• W2108736057 cites W2057070923 @default.
• W2108736057 cites W2062444881 @default.
• W2108736057 cites W2065336454 @default.
• W2108736057 cites W2066973526 @default.
• W2108736057 cites W2075757507 @default.
• W2108736057 cites W2078159546 @default.
• W2108736057 cites W2082318061 @default.
• W2108736057 cites W2089082314 @default.
• W2108736057 cites W2094543356 @default.
• W2108736057 cites W2099302662 @default.
• W2108736057 cites W2101995865 @default.
• W2108736057 cites W2107931058 @default.
• W2108736057 cites W2114441824 @default.
• W2108736057 cites W2116787167 @default.
• W2108736057 cites W2116918515 @default.
• W2108736057 cites W2117305280 @default.
• W2108736057 cites W2130866079 @default.
• W2108736057 cites W2154313625 @default.
• W2108736057 cites W2156010010 @default.
• W2108736057 cites W2162929947 @default.
• W2108736057 doi "https://doi.org/10.1158/1078-0432.ccr-09-2351" @default.
• W2108736057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20400521" @default.
• W2108736057 hasPublicationYear "2010" @default.
• W2108736057 type Work @default.
• W2108736057 sameAs 2108736057 @default.
• W2108736057 citedByCount "19" @default.
• W2108736057 countsByYear W21087360572012 @default.
• W2108736057 countsByYear W21087360572013 @default.
• W2108736057 countsByYear W21087360572014 @default.
• W2108736057 countsByYear W21087360572015 @default.
• W2108736057 countsByYear W21087360572016 @default.
• W2108736057 countsByYear W21087360572018 @default.
• W2108736057 countsByYear W21087360572019 @default.
• W2108736057 countsByYear W21087360572023 @default.
• W2108736057 crossrefType "journal-article" @default.
• W2108736057 hasAuthorship W2108736057A5001649072 @default.
• W2108736057 hasAuthorship W2108736057A5010153046 @default.
• W2108736057 hasAuthorship W2108736057A5017396692 @default.
• W2108736057 hasAuthorship W2108736057A5019504883 @default.
• W2108736057 hasAuthorship W2108736057A5023487576 @default.
• W2108736057 hasAuthorship W2108736057A5030299515 @default.
• W2108736057 hasAuthorship W2108736057A5032933031 @default.
• W2108736057 hasAuthorship W2108736057A5032949456 @default.
• W2108736057 hasAuthorship W2108736057A5048976108 @default.
• W2108736057 hasAuthorship W2108736057A5063899863 @default.
• W2108736057 hasAuthorship W2108736057A5088559019 @default.
• W2108736057 hasAuthorship W2108736057A5090245498 @default.
• W2108736057 hasBestOaLocation W21087360572 @default.
• W2108736057 hasConcept C104317684 @default.
• W2108736057 hasConcept C121608353 @default.
• W2108736057 hasConcept C126322002 @default.
• W2108736057 hasConcept C127561419 @default.
• W2108736057 hasConcept C142724271 @default.
• W2108736057 hasConcept C143998085 @default.
• W2108736057 hasConcept C193270364 @default.
• W2108736057 hasConcept C204232928 @default.
• W2108736057 hasConcept C2776694085 @default.
• W2108736057 hasConcept C2781303535 @default.
• W2108736057 hasConcept C502942594 @default.
• W2108736057 hasConcept C530470458 @default.
• W2108736057 hasConcept C55493867 @default.
• W2108736057 hasConcept C71924100 @default.
• W2108736057 hasConcept C84606932 @default.
• W2108736057 hasConcept C86803240 @default.
• W2108736057 hasConcept C98717036 @default.
• W2108736057 hasConceptScore W2108736057C104317684 @default.
• W2108736057 hasConceptScore W2108736057C121608353 @default.
• W2108736057 hasConceptScore W2108736057C126322002 @default.

• next