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- W2108736063 abstract "Alzheimer's disease (AD) is the most common form of dementia and is characterized clinically by a gradual decline in cognitive performance, an increasingly impaired ability to perform activities of daily living, and behavioral and psychological symptoms of dementia (BPSD). Objective: The objective is to compare the effects of memantine add-on therapy to rivastigmine transdermal patches with monotherapy on the BPSD in mild-to-moderate AD. Two hundred and six patients with probable AD and Korean mini-mental state examination (K-MMSE) scores of 10 to 20 started on a 5-cm 2 rivastigmine patch and the dose was increased to a 10-cm 2 patch after 4 weeks. After the 8-week run-in period, 172 were randomized to rivastigmine patch monotherapy or memantine add-on therapy for 16 weeks. We employed the Korean Version of Cohen Mansfield Agitation Inventory (CMAI-K) and Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), administered at baseline, week 8, and week 24, to assess the effects of treatment on behavior. Global, cognitive, and functional measures were collected and relationships between these assessments and changes in behavior were determined. The intent-to-treat population was examined using last-observation-carried-forward and observed-cases approaches. In the current study, combination therapy with memantine did not show an advantage on the BPSD in mild-to-moderate AD, compared with rivastigmine patch monotherapy." @default.
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- W2108736063 date "2012-07-01" @default.
- W2108736063 modified "2023-10-16" @default.
- W2108736063 title "P3-365: Effect of combination therapy with memantine and rivastigmine transdermal patch on BPSD in patients with mild-to-moderate Alzheimer's disease: A 24-week prospective, multicenter, randomized, open-label clinical trial" @default.
- W2108736063 doi "https://doi.org/10.1016/j.jalz.2012.05.1590" @default.
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