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- W2108746035 abstract "Transdermal delivery of fentanyl has become popular for the treatment of chronic pain. In 1990, the US Food and Drug Administration initially approved Alza Corporation's Duragesic patch; since this time, numerous reports have demonstrated the potential for toxicity and abuse of such devices. 1 Mylan Technologies. Generic fentanyl transdermal system (Duragesic patch). Drug Formulary Rev. 2005; 21: 24 Google Scholar These patches typically contain large amounts of fentanyl, up to 10 mg, sufficient for 3 days of use. They have been substituted for heroin, used as an agent for suicide, and surreptitiously administered by physician narcotic addicts. Opioid toxicity has been reported when patches are dissolved into “teas,” applied overzealously to the skin, inhaled, eaten, and even injected intravenously. 2 Barrueto Jr., F. Howland M.A. Hoffman R.S. et al. The fentanyl tea bag. Vet Hum Toxicol. 2004; 46: 30-31 PubMed Google Scholar , 3 Edinboro L.E. Poklis A. Trautman D. et al. Fatal fentanyl intoxication following excessive transdermal application. J Forensic Sci. 1997; 42: 741-743 Crossref PubMed Google Scholar , 4 Marquardt K.A. Tharratt R.S. Inhalation abuse of fentanyl patch. J Toxicol Clin Toxicol. 1994; 32: 75-78 Crossref PubMed Scopus (98) Google Scholar Recently, we encountered an interesting case of a purposeful suicide attempt with rectal patch insertion. Although mucosal absorption by ingestion or sucking is well known, this is the first known case of opioid toxicity from rectal fentanyl patch insertion." @default.
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- W2108746035 date "2005-11-01" @default.
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- W2108746035 title "Rectal Insertion of Fentanyl Patches: A New Route of Toxicity" @default.
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- W2108746035 doi "https://doi.org/10.1016/j.annemergmed.2005.06.450" @default.
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