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• W2108752451 abstract "Background Caesarean section rates are increasing. It is not clear whether a familial predisposition to caesarean section exists. Methods Births registered in the Medical Birth Registry of Norway during 1967–2005 were linked to construct 440 236 grandmother–parent units and 275 001 same sex full sibling units. Log-binomial regression models were used to explore associations. Results A mother born by caesarean section had a 55% increased risk of having her first child by caesarean section [adjusted relative risk (RR) 1.55, 95% CI 1.48–1.62]. The same was not found for fathers born by caesarean section (RR 1.02, 95% CI 0.96–1.10). A younger sister, whose older sister had her first child by caesarean section, had a 45% increased risk of having her first child by caesarean section (RR 1.45, 95% CI 1.40–1.51). If an older brother had his first child by caesarean, this did not constitute an increased risk for the younger brother's partner (RR 1.02, 95% CI 0.97–1.08). Similar associations were found in the subgroups of obstetric low risk deliveries. Conclusions A female-to-female familial predisposition to caesarean section was observed. It could be caused by biologic inheritance, primarily working through maternal alleles and/or environmental factors. The results imply that both mechanisms could be important." @default.
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• W2108752451 date "2008-06-07" @default.
• W2108752451 modified "2023-10-15" @default.
• W2108752451 title "Caesarean section among relatives" @default.
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• W2108752451 doi "https://doi.org/10.1093/ije/dyn100" @default.
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