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• W2108754806 abstract "Abstract: Paternity testing is being increasingly requested with the aim of challenging presumptive fatherhood. The ability to establish the biological father is usually based on the genotyping of autosomal short tandem repeat (STR) in alleged father, mother and child, but the use of Y‐chromosomal STR has gained interest in the last few years. In this work, we propose a new probabilistic approach that combines autosomal and Y‐chromosomal STR data in paternity testing with father/son pairs taking into account mutation events. We also suggest a new two‐stage approach where we first type Y‐STRs and possibly autosomal STR for the putative father and son, conditional on Y‐STR results. We applied this approach to 22 cases. Our results show that Y‐STRs can identify nonpaternity cases with high accuracy but need to be validated with autosomal STR to establish paternity. Moreover, the two‐stage approach is less costly than the standard approach and is very useful in motherless cases." @default.
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• W2108754806 date "2007-08-28" @default.
• W2108754806 modified "2023-10-15" @default.
• W2108754806 title "Combining Autosomal and Y-Chromosomal Short Tandem Repeat Data in Paternity Testing with Male Child: Methods and Application" @default.
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• W2108754806 doi "https://doi.org/10.1111/j.1556-4029.2007.00513.x" @default.
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