Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108758701> ?p ?o ?g. }
- W2108758701 endingPage "3604" @default.
- W2108758701 startingPage "3595" @default.
- W2108758701 abstract "Chronic ovulation as a contributing factor for the development of epithelial ovarian cancer in women has long been an outstanding hypothesis. To test the incessant ovulation hypothesis, mice were superovulated using weekly ip injections of pregnant mare serum gonadotropin (5 IU/animal), followed 48 h later by human chorionic gonadotropin (5 IU/animal). Wild-type CD1 mice were used along with CD1 mice expressing a Smad2 dominant-negative (Smad2DN) transgene under the control of the Müllerian inhibiting substance promoter that targets expression to the ovary and enhances cyst formation. After chronic injections, ovaries were analyzed from animals 6 months of age for the total adjusted number of cysts, cyst area, cyst location, and key signaling pathways. All observed cysts were confirmed to be of epithelial origin. The number of cysts was not significantly different between superovulated and control mice in either the wild-type or Smad2DN groups. However, the combination of the Smad2DN transgene and superovulation resulted in an increase in cyst formation compared with normal littermates that were unstimulated. Rapid proliferation of the cells lining the cysts was detected using bromodeoxyuridine and phospho-histone 3 immunohistochemistry but was not different in the ovarian surface epithelium or in the cyst lining between groups. These data suggest that chronic superovulation in Smad2DN mice results in a higher incidence of cyst formation compared with unstimulated controls, but the epithelial lined cysts did not progress to cancer over the course of this study." @default.
- W2108758701 created "2016-06-24" @default.
- W2108758701 creator A5014791727 @default.
- W2108758701 creator A5020874227 @default.
- W2108758701 creator A5031132546 @default.
- W2108758701 creator A5032494022 @default.
- W2108758701 creator A5055696858 @default.
- W2108758701 creator A5068626380 @default.
- W2108758701 date "2007-08-01" @default.
- W2108758701 modified "2023-09-28" @default.
- W2108758701 title "Ovarian Epithelial Inclusion Cysts in Chronically Superovulated CD1 and Smad2 Dominant-Negative Mice" @default.
- W2108758701 cites W136092066 @default.
- W2108758701 cites W1514397065 @default.
- W2108758701 cites W1557763750 @default.
- W2108758701 cites W1608847346 @default.
- W2108758701 cites W174535541 @default.
- W2108758701 cites W1840787377 @default.
- W2108758701 cites W1965068333 @default.
- W2108758701 cites W1969289256 @default.
- W2108758701 cites W1981064972 @default.
- W2108758701 cites W1981489196 @default.
- W2108758701 cites W1984044929 @default.
- W2108758701 cites W1985533709 @default.
- W2108758701 cites W1988499895 @default.
- W2108758701 cites W1990098574 @default.
- W2108758701 cites W1992719907 @default.
- W2108758701 cites W1997647901 @default.
- W2108758701 cites W2000913167 @default.
- W2108758701 cites W2003979959 @default.
- W2108758701 cites W2005020146 @default.
- W2108758701 cites W2006945006 @default.
- W2108758701 cites W2007005555 @default.
- W2108758701 cites W2010317565 @default.
- W2108758701 cites W2017926643 @default.
- W2108758701 cites W2024065542 @default.
- W2108758701 cites W2030175428 @default.
- W2108758701 cites W2032480789 @default.
- W2108758701 cites W2034867790 @default.
- W2108758701 cites W2036850058 @default.
- W2108758701 cites W2038206330 @default.
- W2108758701 cites W2042500605 @default.
- W2108758701 cites W2049723889 @default.
- W2108758701 cites W2053426793 @default.
- W2108758701 cites W2055832348 @default.
- W2108758701 cites W2058503472 @default.
- W2108758701 cites W2059213440 @default.
- W2108758701 cites W2062495971 @default.
- W2108758701 cites W2077037952 @default.
- W2108758701 cites W2078623717 @default.
- W2108758701 cites W2079155618 @default.
- W2108758701 cites W2080774468 @default.
- W2108758701 cites W2086860456 @default.
- W2108758701 cites W2091852284 @default.
- W2108758701 cites W2097938363 @default.
- W2108758701 cites W2106437437 @default.
- W2108758701 cites W2107506334 @default.
- W2108758701 cites W2108217153 @default.
- W2108758701 cites W2119456453 @default.
- W2108758701 cites W2120270970 @default.
- W2108758701 cites W2121284603 @default.
- W2108758701 cites W2127706095 @default.
- W2108758701 cites W2137956841 @default.
- W2108758701 cites W2138003270 @default.
- W2108758701 cites W2138202356 @default.
- W2108758701 cites W2138468070 @default.
- W2108758701 cites W2139222330 @default.
- W2108758701 cites W2142819014 @default.
- W2108758701 cites W2148976855 @default.
- W2108758701 cites W2151417473 @default.
- W2108758701 cites W2155038559 @default.
- W2108758701 cites W2155921775 @default.
- W2108758701 cites W2158403875 @default.
- W2108758701 cites W2159118954 @default.
- W2108758701 cites W2161704600 @default.
- W2108758701 cites W2162206673 @default.
- W2108758701 cites W2166473248 @default.
- W2108758701 cites W2166500526 @default.
- W2108758701 cites W2169729289 @default.
- W2108758701 cites W2171249989 @default.
- W2108758701 cites W2186618994 @default.
- W2108758701 cites W2413411562 @default.
- W2108758701 cites W2734846420 @default.
- W2108758701 cites W2286606723 @default.
- W2108758701 doi "https://doi.org/10.1210/en.2007-0030" @default.
- W2108758701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17431007" @default.
- W2108758701 hasPublicationYear "2007" @default.
- W2108758701 type Work @default.
- W2108758701 sameAs 2108758701 @default.
- W2108758701 citedByCount "18" @default.
- W2108758701 countsByYear W21087587012012 @default.
- W2108758701 countsByYear W21087587012013 @default.
- W2108758701 countsByYear W21087587012014 @default.
- W2108758701 countsByYear W21087587012016 @default.
- W2108758701 countsByYear W21087587012018 @default.
- W2108758701 countsByYear W21087587012019 @default.
- W2108758701 countsByYear W21087587012023 @default.
- W2108758701 crossrefType "journal-article" @default.
- W2108758701 hasAuthorship W2108758701A5014791727 @default.