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• W2108760918 abstract "Abstract This study was undertaken to define the role of P-glycoprotein (P-glyc), as a marker of multidrug resistance (MDR) and to determine if it would predict both response to chemotherapy and prognosis in 42 previously untreated patients with advanced breast carcinoma. P-glyc was assayed using the monoclonal antibody (Mab) JSB-1 using an immunocytochemical method. On the same tumours, the following biological features were also estimated: tumour angiogenesis, epidermal growth factor receptor, c-erbB-2 oncoprotein and growth fraction using immunohistochemistry with immunocytochemically factor VIII-related antigen, EGFR1 Mab, 21N antibody and Ki-67 Mab, respectively. Overall, 50% of carcinomas were JSB-1 positive and the presence of P-glyc was not significantly associated with any other factor, but it was significantly predictive of poor response with anthracycline based chemotherapy (p=0.03). Moreover, lack of initial response to chemotherapy was significantly correlated with the percentage of cells staining with the JSB-1 antibody (p=0.016). P-glyc expression and the proportion of cells staining as JSB-1 positive correlated with clinical stage and analysis showed that they significantly predicted response to chemotherapy only in stage IV patients (p=0.015 and p None of the other factors were predictive for response or prognosis. The present study indicates that intrinsic resistance seems to have an important role in the failure of chemotherapy in advanced breast cancer and the determination of P-glyc could be of value to the clinician in identifying those patients (with P-glyc-negative tumours) who are potentially responsive to conventional chemotherapy." @default.
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• W2108760918 date "1993-03-01" @default.
• W2108760918 modified "2023-09-27" @default.
• W2108760918 title "P-glycoprotein expression predicts response to chemotherapy in previously untreated advanced breast cancer" @default.
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• W2108760918 doi "https://doi.org/10.1016/0960-9776(93)90033-c" @default.
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