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- W2108762011 abstract "Advanced glycation end products (AGEs) are proteins or lipids that become glycated after exposure to sugars. AGEs are prevalent in the diabetic vasculature and contribute to the development of atherosclerosis. The presence and accumulation of AGEs in many different cell types affect extracellular and intracellular structure and function. AGEs contribute to a variety of microvascular and macrovascular complications through the formation of cross-links between molecules in the basement membrane of the extracellular matrix and by engaging the receptor for advanced glycation end products (RAGE). Activation of RAGE by AGEs causes upregulation of the transcription factor nuclear factor-κB and its target genes. Soluble AGEs activate monocytes, and AGEs in the basement membrane inhibit monocyte migration. AGE-bound RAGE increases endothelial permeability to macromolecules. AGEs block nitric oxide activity in the endothelium and cause the production of reactive oxygen species. Because of the emerging evidence about the adverse effects of AGEs on the vasculature of patients with diabetes, a number of different therapies to inhibit AGEs are under investigation." @default.
- W2108762011 created "2016-06-24" @default.
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- W2108762011 date "2006-08-08" @default.
- W2108762011 modified "2023-10-18" @default.
- W2108762011 title "Advanced Glycation End Products" @default.
- W2108762011 cites W1481692296 @default.
- W2108762011 cites W1503258737 @default.
- W2108762011 cites W1507214593 @default.
- W2108762011 cites W1510575902 @default.
- W2108762011 cites W1547902391 @default.
- W2108762011 cites W1557253076 @default.
- W2108762011 cites W1572011530 @default.
- W2108762011 cites W1594856996 @default.
- W2108762011 cites W1609735481 @default.
- W2108762011 cites W1640074353 @default.
- W2108762011 cites W1757241200 @default.
- W2108762011 cites W1966234811 @default.
- W2108762011 cites W1967303459 @default.
- W2108762011 cites W1970936597 @default.
- W2108762011 cites W1971209988 @default.
- W2108762011 cites W1971669918 @default.
- W2108762011 cites W1974867437 @default.
- W2108762011 cites W1978611180 @default.
- W2108762011 cites W1979731419 @default.
- W2108762011 cites W1979803629 @default.
- W2108762011 cites W1984830754 @default.
- W2108762011 cites W1986059252 @default.
- W2108762011 cites W1987796811 @default.
- W2108762011 cites W1991683975 @default.
- W2108762011 cites W1995180560 @default.
- W2108762011 cites W1995249907 @default.
- W2108762011 cites W2000896479 @default.
- W2108762011 cites W2005653939 @default.
- W2108762011 cites W2005847047 @default.
- W2108762011 cites W2008181875 @default.
- W2108762011 cites W2008567943 @default.
- W2108762011 cites W2009163301 @default.
- W2108762011 cites W2011955651 @default.
- W2108762011 cites W2013066156 @default.
- W2108762011 cites W2013730613 @default.
- W2108762011 cites W2014420759 @default.
- W2108762011 cites W2014649717 @default.
- W2108762011 cites W2017959010 @default.
- W2108762011 cites W2019226618 @default.
- W2108762011 cites W2019656247 @default.
- W2108762011 cites W2020979704 @default.
- W2108762011 cites W2026885016 @default.
- W2108762011 cites W2028798355 @default.
- W2108762011 cites W2029200573 @default.
- W2108762011 cites W2031234071 @default.
- W2108762011 cites W2036402170 @default.
- W2108762011 cites W2036734998 @default.
- W2108762011 cites W2040005689 @default.
- W2108762011 cites W2047964022 @default.
- W2108762011 cites W2049180796 @default.
- W2108762011 cites W2049262834 @default.
- W2108762011 cites W2056258976 @default.
- W2108762011 cites W2057961754 @default.
- W2108762011 cites W2058597871 @default.
- W2108762011 cites W2060161378 @default.
- W2108762011 cites W2062845551 @default.
- W2108762011 cites W2065556618 @default.
- W2108762011 cites W2065842589 @default.
- W2108762011 cites W2066298745 @default.
- W2108762011 cites W2066512884 @default.
- W2108762011 cites W2066779642 @default.
- W2108762011 cites W2071675524 @default.
- W2108762011 cites W2073232387 @default.
- W2108762011 cites W2073713671 @default.
- W2108762011 cites W2073714833 @default.
- W2108762011 cites W2074706442 @default.
- W2108762011 cites W2079875165 @default.
- W2108762011 cites W2086169454 @default.
- W2108762011 cites W2088056587 @default.
- W2108762011 cites W2089088024 @default.
- W2108762011 cites W2089274943 @default.
- W2108762011 cites W2090205376 @default.
- W2108762011 cites W2095820351 @default.
- W2108762011 cites W2097474009 @default.
- W2108762011 cites W2098407973 @default.
- W2108762011 cites W2101085512 @default.
- W2108762011 cites W2101454824 @default.
- W2108762011 cites W2103815847 @default.
- W2108762011 cites W2106216311 @default.
- W2108762011 cites W2106697731 @default.
- W2108762011 cites W2107307747 @default.
- W2108762011 cites W2110748058 @default.
- W2108762011 cites W2110774866 @default.
- W2108762011 cites W2112203309 @default.
- W2108762011 cites W2114283061 @default.
- W2108762011 cites W2115293825 @default.
- W2108762011 cites W2116458615 @default.
- W2108762011 cites W2117937531 @default.
- W2108762011 cites W2119150369 @default.