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- W2108762904 abstract "Abstract Biopharmaceutical plasma protein products obtained by the industrial fractionation of human plasma or by DNA engineering technologies, most often relying on synthesis in mammalian cell lines, are essential, high‐value added medicines used to treat a variety of congenital or acquired blood coagulation, immunological, or metabolic disorders. The quality of these products is largely dependent upon the characteristics of their extraction procedures which have a direct impact on the protein impurity profile and pathogen safety. Affinity chromatography has developed into a key industrial tool to purify these therapeutic protein products, most particularly those present in trace amounts in plasma. While various immobilized affinity ligands, such as heparin, monoclonal antibodies, and, to a lesser extent, gelatine, have been used for many years to extract or polish coagulation factors, there is now a pronounced interest in the evaluation of specifically designed peptide or mixed‐mode ligands that could improve extraction productivity of a wider range of plasma products, including IgG, alpha 1‐antitrypsin (AAT), and “orphan drug” proteins, like some coagulation factors and anticoagulants. This paper reviews the current status in the use of affinity chromatography procedures in the industrial manufacture of plasma‐derived (PD) and recombinant‐protein therapeutic products." @default.
- W2108762904 created "2016-06-24" @default.
- W2108762904 creator A5006405586 @default.
- W2108762904 creator A5057430248 @default.
- W2108762904 date "2009-12-15" @default.
- W2108762904 modified "2023-10-10" @default.
- W2108762904 title "Affinity Chromatography-Fractionated and DNA-Engineered Plasma Proteins" @default.
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- W2108762904 doi "https://doi.org/10.1002/9780470054581.eib011" @default.
- W2108762904 hasPublicationYear "2009" @default.
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