FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108790695> ?p ?o ?g. }

• W2108790695 endingPage "260" @default.
• W2108790695 startingPage "254" @default.
• W2108790695 abstract "Dysregulation of glutamate neurotransmission is implicated in the pathphysiology of schizophrenia. Vesicular glutamate transporters (VGLUTs) package glutamate into vesicles in the presynaptic terminal and regulate the release of glutamate. Abnormal VGLUT1 expression has been linked to schizophrenia in postmortem brain studies. The purpose of this study was to investigate the involvement of the human VGLUT1 in the susceptibility to schizophrenia. In this study, we searched for genetic variants in the putative core promoter region and 12 exons (including UTR ends) of the VGLUT1 gene using direct sequencing in a sample of Han Chinese schizophrenic patients (n=376) and non-psychotic controls (n=368) from Taiwan, and conducted a case-control association study. We identified two common SNPs (g.-248G>C (ss159695612) and c.2697C>A (rs1043558)) in the VGLUT1 gene. No differences in the allele and genotype frequencies were detected between the patients and control subjects. Besides, we identified eight patient-specific rare variants in 16 out of 376 patients, including two variants (g.-296A>G (ss159695611) and g.-32Cv>T (ss159695613)) at the core promoter region and 5'UTR, two missense variants (L516M (ss159695617) and P551S (ss159695618)) and three silent variants (E24E (ss159695614), L118L (ss159695615), and P133P (ss159695616)) at protein-coding regions, and one variant (c.2201G>A (ss159695619)) at the 3'UTR. No rare variants were found in 368 control subjects (4.3% versus 0, P=1.5x10(-5)). Although the functional significance of these rare variants remains to be characterized, our study may lend support to the multiple rare mutation hypothesis of schizophrenia, and may provide genetic clues to indicate the involvement of the glutamate transmission pathway in the pathogenesis of schizophrenia." @default.
• W2108790695 created "2016-06-24" @default.
• W2108790695 creator A5011396157 @default.
• W2108790695 creator A5047323038 @default.
• W2108790695 creator A5066812595 @default.
• W2108790695 creator A5067482001 @default.
• W2108790695 creator A5067885487 @default.
• W2108790695 creator A5076807634 @default.
• W2108790695 creator A5079514521 @default.
• W2108790695 creator A5087830613 @default.
• W2108790695 creator A5090230191 @default.
• W2108790695 date "2009-12-01" @default.
• W2108790695 modified "2023-09-24" @default.
• W2108790695 title "Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia" @default.
• W2108790695 cites W1271531431 @default.
• W2108790695 cites W1507804974 @default.
• W2108790695 cites W1982504646 @default.
• W2108790695 cites W1984170477 @default.
• W2108790695 cites W1988068514 @default.
• W2108790695 cites W1994332160 @default.
• W2108790695 cites W1998679999 @default.
• W2108790695 cites W1999679029 @default.
• W2108790695 cites W2001813194 @default.
• W2108790695 cites W2005684805 @default.
• W2108790695 cites W2006955548 @default.
• W2108790695 cites W2012827002 @default.
• W2108790695 cites W2015333579 @default.
• W2108790695 cites W2015715942 @default.
• W2108790695 cites W2020620545 @default.
• W2108790695 cites W2023707243 @default.
• W2108790695 cites W2029216106 @default.
• W2108790695 cites W2030447006 @default.
• W2108790695 cites W2037718442 @default.
• W2108790695 cites W2047721309 @default.
• W2108790695 cites W2050359514 @default.
• W2108790695 cites W2054406618 @default.
• W2108790695 cites W2055354052 @default.
• W2108790695 cites W2057355158 @default.
• W2108790695 cites W2065371606 @default.
• W2108790695 cites W2086746594 @default.
• W2108790695 cites W2094137970 @default.
• W2108790695 cites W2100246746 @default.
• W2108790695 cites W2101494517 @default.
• W2108790695 cites W2102098190 @default.
• W2108790695 cites W2105278734 @default.
• W2108790695 cites W2114381854 @default.
• W2108790695 cites W2116641097 @default.
• W2108790695 cites W2126718294 @default.
• W2108790695 cites W2137422526 @default.
• W2108790695 cites W2141808273 @default.
• W2108790695 cites W2142271135 @default.
• W2108790695 cites W2146292332 @default.
• W2108790695 cites W2158137297 @default.
• W2108790695 cites W2172098883 @default.
• W2108790695 cites W2237068250 @default.
• W2108790695 cites W44954597 @default.
• W2108790695 doi "https://doi.org/10.1016/j.schres.2009.08.003" @default.
• W2108790695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19720501" @default.
• W2108790695 hasPublicationYear "2009" @default.
• W2108790695 type Work @default.
• W2108790695 sameAs 2108790695 @default.
• W2108790695 citedByCount "6" @default.
• W2108790695 countsByYear W21087906952013 @default.
• W2108790695 countsByYear W21087906952017 @default.
• W2108790695 countsByYear W21087906952018 @default.
• W2108790695 countsByYear W21087906952021 @default.
• W2108790695 countsByYear W21087906952023 @default.
• W2108790695 crossrefType "journal-article" @default.
• W2108790695 hasAuthorship W2108790695A5011396157 @default.
• W2108790695 hasAuthorship W2108790695A5047323038 @default.
• W2108790695 hasAuthorship W2108790695A5066812595 @default.
• W2108790695 hasAuthorship W2108790695A5067482001 @default.
• W2108790695 hasAuthorship W2108790695A5067885487 @default.
• W2108790695 hasAuthorship W2108790695A5076807634 @default.
• W2108790695 hasAuthorship W2108790695A5079514521 @default.
• W2108790695 hasAuthorship W2108790695A5087830613 @default.
• W2108790695 hasAuthorship W2108790695A5090230191 @default.
• W2108790695 hasConcept C104317684 @default.
• W2108790695 hasConcept C105580179 @default.
• W2108790695 hasConcept C135763542 @default.
• W2108790695 hasConcept C153209595 @default.
• W2108790695 hasConcept C170493617 @default.
• W2108790695 hasConcept C180754005 @default.
• W2108790695 hasConcept C36823959 @default.
• W2108790695 hasConcept C501734568 @default.
• W2108790695 hasConcept C54355233 @default.
• W2108790695 hasConcept C61174792 @default.
• W2108790695 hasConcept C75563809 @default.
• W2108790695 hasConcept C86803240 @default.
• W2108790695 hasConcept C89604277 @default.
• W2108790695 hasConceptScore W2108790695C104317684 @default.
• W2108790695 hasConceptScore W2108790695C105580179 @default.
• W2108790695 hasConceptScore W2108790695C135763542 @default.
• W2108790695 hasConceptScore W2108790695C153209595 @default.
• W2108790695 hasConceptScore W2108790695C170493617 @default.
• W2108790695 hasConceptScore W2108790695C180754005 @default.
• W2108790695 hasConceptScore W2108790695C36823959 @default.
• W2108790695 hasConceptScore W2108790695C501734568 @default.

• next