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• W2108791313 abstract "SUMMARY Vaccination is a feasible strategy for controlling the haematophagous poultry red mite Dermanyssus gallinae . A cDNA library enriched for genes upregulated after feeding was created to identify potential vaccine antigens. From this library, a gene ( Dg-CatD-1 ) encoding a 383 amino acid protein ( Dg -CatD-1) with homology to cathepsin D lysosomal aspartyl proteinases was identified as a potential vaccine candidate. A second gene ( Dg-CatL-1 ) encoding a 341 amino acid protein ( Dg -CatL-1) with homology to cathepsin L cysteine proteinases was also selected for further study. IgY obtained from naturally infested hens failed to detect Dg -CatD-1 suggesting that it is a concealed antigen. Conversely, Dg -CatL-1 was detected by IgY derived from natural-infestation, indicating that infested hens are exposed to Dg -CatL-1. Mortality rates 120 h after mites had been fed anti- Dg -CatD-1 were significantly higher than those fed control IgY ( P F <0·01). In a survival analysis, fitting a proportional hazards model to the time of death of mites, anti- Dg -CatD-1 and anti- Dg -CatL-1 IgY had 4·42 and 2·13 times higher risks of dying compared with controls ( P F <0·05). Dg -CatD-1 and L-1 both have potential as vaccine antigens as part of a multi-component vaccine and have the potential to be improved as vaccine antigens using alternative expression systems." @default.
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• W2108791313 date "2012-02-06" @default.
• W2108791313 modified "2023-10-11" @default.
• W2108791313 title "Assessment of cathepsin D and L-like proteinases of poultry red mite, <i>Dermanyssus gallinae</i> (De Geer), as potential vaccine antigens" @default.
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• W2108791313 doi "https://doi.org/10.1017/s0031182011002356" @default.
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