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- W2108798315 endingPage "421" @default.
- W2108798315 startingPage "415" @default.
- W2108798315 abstract "Since the introduction of antibiotics in the 1930s, <i>Neisseria gonorrhoeae</i> has exhibited a remarkable ability to acquire novel genetic resistance determinants. Initially, sulphonamides were replaced by penicillin, while tetracyclines were prescribed for penicillin-allergic patients. With the advent of penicillinase-producing gonococci, spectinomycin was only briefly useful as alternative treatment and plasmid-mediated tetracycline resistance spread rapidly from the mid-1980s onwards. The fluoroquinolones followed but chromosomally mediated resistance appeared after only a decade of use. Seventy years on, we now face a global public health challenge of immense significance—the emergence of resistance to cephalosporins. With lack of investment in the search for new anti-gonococcal antimicrobial agents or vaccine research, the global spread of multiresistant gonococci can be seen. The impact of untreatable gonorrhoea on HIV transmission could be enormous in high-prevalence countries. This threat comes at a time when many national STI control programmes are weak. To delay the emergence of extensively drug-resistant gonorrhoea, public health systems require strengthening and novel strategies need implementing to enhance the therapeutic lifespan of the few antimicrobial agents that we have left." @default.
- W2108798315 created "2016-06-24" @default.
- W2108798315 creator A5071885441 @default.
- W2108798315 date "2010-07-23" @default.
- W2108798315 modified "2023-10-16" @default.
- W2108798315 title "The Gonococcus fights back: is this time a knock out?" @default.
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