FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108806843> ?p ?o ?g. }

• W2108806843 endingPage "655" @default.
• W2108806843 startingPage "651" @default.
• W2108806843 abstract "Mechanical responsiveness is essential to all biological systems down to the level of tissues and cells. The intra- and extracellular mechanics of such systems are governed by a series of proteins, such as microtubules, actin, intermediate filaments and collagen. As a general design motif, these proteins self-assemble into helical structures and superstructures that differ in diameter and persistence length to cover the full mechanical spectrum. Gels of cytoskeletal proteins display particular mechanical responses (stress stiffening) that until now have been absent in synthetic polymeric and low-molar-mass gels. Here we present synthetic gels that mimic in nearly all aspects gels prepared from intermediate filaments. They are prepared from polyisocyanopeptides grafted with oligo(ethylene glycol) side chains. These responsive polymers possess a stiff and helical architecture, and show a tunable thermal transition where the chains bundle together to generate transparent gels at extremely low concentrations. Using characterization techniques operating at different length scales (for example, macroscopic rheology, atomic force microscopy and molecular force spectroscopy) combined with an appropriate theoretical network model, we establish the hierarchical relationship between the bulk mechanical properties and the single-molecule parameters. Our results show that to develop artificial cytoskeletal or extracellular matrix mimics, the essential design parameters are not only the molecular stiffness, but also the extent of bundling. In contrast to the peptidic materials, our polyisocyanide polymers are readily modified, giving a starting point for functional biomimetic hydrogels with potentially a wide variety of applications, in particular in the biomedical field." @default.
• W2108806843 created "2016-06-24" @default.
• W2108806843 creator A5008192334 @default.
• W2108806843 creator A5025516897 @default.
• W2108806843 creator A5036080001 @default.
• W2108806843 creator A5043082341 @default.
• W2108806843 creator A5043545998 @default.
• W2108806843 creator A5054596419 @default.
• W2108806843 creator A5056739754 @default.
• W2108806843 creator A5063114673 @default.
• W2108806843 creator A5065117635 @default.
• W2108806843 creator A5066976932 @default.
• W2108806843 creator A5071435223 @default.
• W2108806843 creator A5075557766 @default.
• W2108806843 creator A5085348171 @default.
• W2108806843 creator A5088963010 @default.
• W2108806843 date "2013-01-01" @default.
• W2108806843 modified "2023-10-10" @default.
• W2108806843 title "Responsive biomimetic networks from polyisocyanopeptide hydrogels" @default.
• W2108806843 cites W1747554369 @default.
• W2108806843 cites W1978533003 @default.
• W2108806843 cites W1989589914 @default.
• W2108806843 cites W1991043063 @default.
• W2108806843 cites W2016747572 @default.
• W2108806843 cites W2022099384 @default.
• W2108806843 cites W2025899422 @default.
• W2108806843 cites W2035629093 @default.
• W2108806843 cites W2036475903 @default.
• W2108806843 cites W2042025816 @default.
• W2108806843 cites W2050186721 @default.
• W2108806843 cites W2070723383 @default.
• W2108806843 cites W2075866529 @default.
• W2108806843 cites W2080588893 @default.
• W2108806843 cites W2092662468 @default.
• W2108806843 cites W2101310101 @default.
• W2108806843 cites W2117425975 @default.
• W2108806843 cites W2121707980 @default.
• W2108806843 cites W2123676567 @default.
• W2108806843 cites W2126531317 @default.
• W2108806843 cites W2132551021 @default.
• W2108806843 cites W2133797478 @default.
• W2108806843 cites W2135977869 @default.
• W2108806843 cites W2166871728 @default.
• W2108806843 doi "https://doi.org/10.1038/nature11839" @default.
• W2108806843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23354048" @default.
• W2108806843 hasPublicationYear "2013" @default.
• W2108806843 type Work @default.
• W2108806843 sameAs 2108806843 @default.
• W2108806843 citedByCount "420" @default.
• W2108806843 countsByYear W21088068432013 @default.
• W2108806843 countsByYear W21088068432014 @default.
• W2108806843 countsByYear W21088068432015 @default.
• W2108806843 countsByYear W21088068432016 @default.
• W2108806843 countsByYear W21088068432017 @default.
• W2108806843 countsByYear W21088068432018 @default.
• W2108806843 countsByYear W21088068432019 @default.
• W2108806843 countsByYear W21088068432020 @default.
• W2108806843 countsByYear W21088068432021 @default.
• W2108806843 countsByYear W21088068432022 @default.
• W2108806843 countsByYear W21088068432023 @default.
• W2108806843 crossrefType "journal-article" @default.
• W2108806843 hasAuthorship W2108806843A5008192334 @default.
• W2108806843 hasAuthorship W2108806843A5025516897 @default.
• W2108806843 hasAuthorship W2108806843A5036080001 @default.
• W2108806843 hasAuthorship W2108806843A5043082341 @default.
• W2108806843 hasAuthorship W2108806843A5043545998 @default.
• W2108806843 hasAuthorship W2108806843A5054596419 @default.
• W2108806843 hasAuthorship W2108806843A5056739754 @default.
• W2108806843 hasAuthorship W2108806843A5063114673 @default.
• W2108806843 hasAuthorship W2108806843A5065117635 @default.
• W2108806843 hasAuthorship W2108806843A5066976932 @default.
• W2108806843 hasAuthorship W2108806843A5071435223 @default.
• W2108806843 hasAuthorship W2108806843A5075557766 @default.
• W2108806843 hasAuthorship W2108806843A5085348171 @default.
• W2108806843 hasAuthorship W2108806843A5088963010 @default.
• W2108806843 hasBestOaLocation W21088068432 @default.
• W2108806843 hasConcept C102951782 @default.
• W2108806843 hasConcept C108586683 @default.
• W2108806843 hasConcept C119473381 @default.
• W2108806843 hasConcept C12554922 @default.
• W2108806843 hasConcept C142669718 @default.
• W2108806843 hasConcept C1491633281 @default.
• W2108806843 hasConcept C159985019 @default.
• W2108806843 hasConcept C171250308 @default.
• W2108806843 hasConcept C178790620 @default.
• W2108806843 hasConcept C185592680 @default.
• W2108806843 hasConcept C188027245 @default.
• W2108806843 hasConcept C192562407 @default.
• W2108806843 hasConcept C200990466 @default.
• W2108806843 hasConcept C2777516009 @default.
• W2108806843 hasConcept C521977710 @default.
• W2108806843 hasConcept C55493867 @default.
• W2108806843 hasConcept C86803240 @default.
• W2108806843 hasConcept C99895341 @default.
• W2108806843 hasConceptScore W2108806843C102951782 @default.
• W2108806843 hasConceptScore W2108806843C108586683 @default.
• W2108806843 hasConceptScore W2108806843C119473381 @default.
• W2108806843 hasConceptScore W2108806843C12554922 @default.

• next