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- W2108807480 abstract "Results from localization ROC (LROC) observer studies evaluating a penalized-likelihood SPECT reconstruction algorithm are presented. Both human and numerical observers were employed for the task of Ga-67 tumor detection in simulated chest images. Projection data from a mathematical phantom were generated with the SIMIND Monte Carlo program. Reconstructions using De Pierro's modified-EM algorithm with the 3D quadratic and Huber penalty functions were Performed. Iterative corrections for nonuniform attenuation, collimator response, and in-patient scatter were included. The LROC studies with these images provided an initial validation of a channelized nonprewhitening (CNPW) numerical observer that explicitly performs the tumor search task, and at the same time demonstrated the usefulness of frequency-selective channels for modeling human detection-task performance. Results drawn from the CNPW observer indicate that for the range of iterations tested, relatively low levels of noise regularization are desirable in the penalized-likelihood images." @default.
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- W2108807480 date "2003-11-20" @default.
- W2108807480 modified "2023-09-30" @default.
- W2108807480 title "Ga-67 tumor detection using penalized-EM with nonanatomical regularizers" @default.
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- W2108807480 doi "https://doi.org/10.1109/nssmic.2002.1239582" @default.
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