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• W2108808959 abstract "Purpose: Biallelic germline variants of the 8-hydroxyguanine (8-OG) repair gene MYH have been associated with colorectal neoplasms that display somatic <TEX>$G:C{rightarrow}T:A$</TEX> transversions. However, the effect of single germline variants has not been widely studied, prompting the present investigation of monoallelic MYH variants and susceptibility to sporadic colorectal cancer (CRC) in a Chinese population. Patients and Methods: Between January 2006 and December 2012, 400 cases of sporadic CRC and 600 age- and sex-matched normal blood donors were screened randomly for 7 potentially pathogenic germline MYH exons using genetic testing technology. Variants of heterozygosity at the MYH locus were assessed in both sporadic cancer patients and healthy controls. Univariate and multivariate analyses were performed to determine risk factors for cancer onset. Results: Five monoallelic single nucleotide polymorphisms (SNPs) were identified in the 7 exon regions of MYH, which were detected in 75 (18.75%) of 400 CRC patients as well as 42 (7%) of 600 normal controls. The region of exon 1 proved to be a linked polymorphic region for the first time, a triple linked variant including exon 1-316 <TEX>$G{rightarrow}A$</TEX>, exon 1-292 <TEX>$G{rightarro</TEX><TEX>w}A$</TEX> and intron 1+11 <TEX>$C{rightarrow}T$</TEX>, being identified in 13 CRC patients and 2 normal blood donors. A variant of base replacement, intron 10-2 <TEX>$A{rightarrow}G$</TEX>, was identified in the exon 10 region in 21 cases and 7 controls, while a similar type of variant in the exon 13 region, intron 13+12 <TEX>$C{rightarrow}T$</TEX>, was identified in 8 cases and 6 controls. Not the only but a newly missense variant in the present study, p. V463E (Exon 14+74 <TEX>$T{rightarrow}A$</TEX>), was identified in exon 14 in 6 patients and 1 normal control. In exon 16, nt. 1678-80 del GTT with loss of heterozygosity (LOH) was identified in 27 CRC cases and 26 controls. There was no Y165C in exon 7 or G382D in exon 14, the hot-spot variants which have been reported most frequently in Caucasian studies. After univariate analysis and multivariate analysis, the linked variant in exon 1 region (p=0.002), intron 10-2 <TEX>$A{rightarrow}G$</TEX> (p=0.004) and p. V463E (p=0.036) in the MYH gene were selected as 3 independent risk factors for CRC. Conclusions: According to these results, the linked variant in Exon 1 region, Intron 10-2 <TEX>$A{rightarrow}G$</TEX> of base replacement and p. V463E of missense variant, the 3 heterozygosity variants of MYH gene in a Chinese population, may relate to the susceptibility to sporadic CRC. Lack of the hot-spot variants of Caucasians in the present study may due to the ethnic difference in MYH gene." @default.
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• W2108808959 date "2013-11-30" @default.
• W2108808959 modified "2023-09-25" @default.
• W2108808959 title "Role of MYH Polymorphisms in Sporadic Colorectal Cancer in China: A Case-control, Population-based Study" @default.
• W2108808959 cites W1970566518 @default.
• W2108808959 cites W1976486964 @default.
• W2108808959 cites W1977127546 @default.
• W2108808959 cites W1984197891 @default.
• W2108808959 cites W1986848665 @default.
• W2108808959 cites W2001258296 @default.
• W2108808959 cites W2019190395 @default.
• W2108808959 cites W2026895762 @default.
• W2108808959 cites W2030455903 @default.
• W2108808959 cites W2043692125 @default.
• W2108808959 cites W2046016850 @default.
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• W2108808959 cites W2047861171 @default.
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• W2108808959 cites W2050599890 @default.
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• W2108808959 cites W2056801173 @default.
• W2108808959 cites W2067431794 @default.
• W2108808959 cites W2068400261 @default.
• W2108808959 cites W2075735771 @default.
• W2108808959 cites W2087753936 @default.
• W2108808959 cites W2095729815 @default.
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• W2108808959 cites W2116485341 @default.
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• W2108808959 cites W2120782088 @default.
• W2108808959 cites W2123127261 @default.
• W2108808959 cites W2123587905 @default.
• W2108808959 cites W2124719572 @default.
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• W2108808959 doi "https://doi.org/10.7314/apjcp.2013.14.11.6403" @default.
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