FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108842014> ?p ?o ?g. }

• W2108842014 abstract "Consensus statements recommend the addition of long-acting inhaled ss2-agonists (LABA) only in asthmatic patients who are inadequately controlled on inhaled corticosteroids (ICS). It is not uncommon for some patients to be commenced on ICS and LABA together as initial therapy.To compare the efficacy of combining inhaled corticosteroids with long-acting ss2-agonists (ICS+LABA) with inhaled corticosteroids alone (ICS alone) in steroid-naive children and adults with persistent asthma. We assessed two protocols: (1) LABA + ICS versus a similar dose of ICS (comparison 1) and (2) LABA + ICS versus a higher dose of ICS (comparison 2).We identified randomised controlled trials through electronic database searches (May 2008).Randomised trials comparing ICS + LABA with ICS alone in children and adults with asthma who had no inhaled corticosteroids in the preceding 28 days prior to enrolment.Each author assessed studies independently for risk of bias and extracted data. We obtained confirmation from the trialists when possible. The primary endpoint was rate of patients with one or more asthma exacerbations requiring rescue systemic corticosteroids. Results are expressed as relative risks (RR) for dichotomous data and as mean differences (MD) or standardised mean differences (SMD) for continuous data.Twenty-eight study comparisons drawn from 27 trials (22 adult; five paediatric) met the review entry criteria (8050 participants). Baseline data from the studies indicated that trial populations had moderate or mild airway obstruction (FEV1>/=65% predicted), and that they were symptomatic prior to randomisation. In comparison 1, the combination of ICS and LABA was not associated with a significantly lower risk of patients with exacerbations requiring oral corticosteroids (RR 1.04; 95% confidence interval (CI) 0.73 to 1.47) or requiring hospital admissions (RR 0.38; 95% CI 0.09 to 1.65) compared to a similar dose of ICS alone. The combination of LABA and ICS led to a significantly greater improvement from baseline in FEV1 (0.12 L/sec; 95% CI 0.07 to 0.17), in symptoms (SMD -0.26; 95% CI -0.37 to -0.14) and in rescue ss2-agonist use (-0.41 puffs/day; 95% CI -0.73 to -0.09) compared with a similar dose of ICS alone. There was no significant group difference in the risk of serious adverse events (RR 1.15; 95% CI 0.64 to 2.09), any adverse events (RR 1.02; 95% CI 0.96 to 1.09), study withdrawals (RR 0.95; 95% CI 0.82 to 1.11), or withdrawals due to poor asthma control (RR 0.94; 95% CI 0.63 to 1.41).In comparison 2, the combination of LABA and ICS was associated with a higher risk of patients requiring oral corticosteroids (RR 1.24; 95% CI 1 to 1.53) and study withdrawal (RR 1.31; 95% CI 1.07 to 1.59) than a higher dose of ICS alone. For every 100 patients treated over 43 weeks, nine patients using a higher dose ICS compared to 11 (95% CI 9 to 14) on LABA and ICS suffered one or more exacerbations requiring rescue oral corticosteroids. There was a high level of statistical heterogeneity for FEV1 and morning peak flow. There was no statistically significant group difference in the risk of serious adverse events. Due to insufficient data we could not aggregate results for hospital admission, symptoms and other outcomes.In steroid-naive patients with mild to moderate airway obstruction, the combination of ICS and LABA does not significantly reduce the risk of patients with exacerbations requiring rescue oral corticosteroids over that achieved with a similar dose of ICS alone. However, it significantly improves lung function, reduces symptoms and marginally decreases rescue ss2-agonist use. Initiation of a higher dose of ICS is more effective at reducing the risk of exacerbations requiring rescue systemic corticosteroids, and of withdrawals, than combination therapy. Although children appeared to respond similarly to adults, no firm conclusions can be drawn regarding combination therapy in steroid-naive children, given the small number of children contributing data." @default.
• W2108842014 created "2016-06-24" @default.
• W2108842014 creator A5043827954 @default.
• W2108842014 creator A5056412174 @default.
• W2108842014 creator A5064914332 @default.
• W2108842014 creator A5065533338 @default.
• W2108842014 date "2009-10-07" @default.
• W2108842014 modified "2023-10-04" @default.
• W2108842014 title "Addition of long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children" @default.
• W2108842014 cites W1505053727 @default.
• W2108842014 cites W1543855637 @default.
• W2108842014 cites W1555651758 @default.
• W2108842014 cites W1572030781 @default.
• W2108842014 cites W1574267174 @default.
• W2108842014 cites W1594570351 @default.
• W2108842014 cites W1598602811 @default.
• W2108842014 cites W1723887941 @default.
• W2108842014 cites W1759878934 @default.
• W2108842014 cites W1760629554 @default.
• W2108842014 cites W1762723501 @default.
• W2108842014 cites W176572879 @default.
• W2108842014 cites W1795103282 @default.
• W2108842014 cites W1852853248 @default.
• W2108842014 cites W1856029611 @default.
• W2108842014 cites W1868621599 @default.
• W2108842014 cites W1902445705 @default.
• W2108842014 cites W1903824044 @default.
• W2108842014 cites W1931016737 @default.
• W2108842014 cites W1963541521 @default.
• W2108842014 cites W1963804030 @default.
• W2108842014 cites W1965221209 @default.
• W2108842014 cites W1965973512 @default.
• W2108842014 cites W1967221017 @default.
• W2108842014 cites W1973413819 @default.
• W2108842014 cites W1974121972 @default.
• W2108842014 cites W1974632345 @default.
• W2108842014 cites W1975097429 @default.
• W2108842014 cites W1975315932 @default.
• W2108842014 cites W1976829610 @default.
• W2108842014 cites W1977438423 @default.
• W2108842014 cites W1979052047 @default.
• W2108842014 cites W1981325629 @default.
• W2108842014 cites W1981638219 @default.
• W2108842014 cites W1981748384 @default.
• W2108842014 cites W1981991229 @default.
• W2108842014 cites W1981992864 @default.
• W2108842014 cites W1982060405 @default.
• W2108842014 cites W1982782019 @default.
• W2108842014 cites W1984300410 @default.
• W2108842014 cites W1985625630 @default.
• W2108842014 cites W1986323240 @default.
• W2108842014 cites W1986759659 @default.
• W2108842014 cites W1987062528 @default.
• W2108842014 cites W1987343787 @default.
• W2108842014 cites W1987928133 @default.
• W2108842014 cites W1988960955 @default.
• W2108842014 cites W1992406604 @default.
• W2108842014 cites W1995129283 @default.
• W2108842014 cites W1995797675 @default.
• W2108842014 cites W1996242416 @default.
• W2108842014 cites W1998329899 @default.
• W2108842014 cites W1998380622 @default.
• W2108842014 cites W1998545217 @default.
• W2108842014 cites W1999413408 @default.
• W2108842014 cites W1999493130 @default.
• W2108842014 cites W1999820108 @default.
• W2108842014 cites W2000522781 @default.
• W2108842014 cites W2000947887 @default.
• W2108842014 cites W2002233703 @default.
• W2108842014 cites W2002899996 @default.
• W2108842014 cites W2003486814 @default.
• W2108842014 cites W2004371282 @default.
• W2108842014 cites W2004483078 @default.
• W2108842014 cites W2006131537 @default.
• W2108842014 cites W2006436081 @default.
• W2108842014 cites W2007283066 @default.
• W2108842014 cites W2007434636 @default.
• W2108842014 cites W2007944175 @default.
• W2108842014 cites W2009453368 @default.
• W2108842014 cites W2010262399 @default.
• W2108842014 cites W2010350605 @default.
• W2108842014 cites W2010733043 @default.
• W2108842014 cites W2010822535 @default.
• W2108842014 cites W2010867332 @default.
• W2108842014 cites W2010966573 @default.
• W2108842014 cites W2011487006 @default.
• W2108842014 cites W2012047031 @default.
• W2108842014 cites W2012700480 @default.
• W2108842014 cites W2013037468 @default.
• W2108842014 cites W2013949673 @default.
• W2108842014 cites W2014561368 @default.
• W2108842014 cites W2014619371 @default.
• W2108842014 cites W2017601887 @default.
• W2108842014 cites W2018270746 @default.
• W2108842014 cites W2019667036 @default.
• W2108842014 cites W2020046121 @default.
• W2108842014 cites W2020544746 @default.
• W2108842014 cites W2022008229 @default.
• W2108842014 cites W2023968105 @default.
• W2108842014 cites W2024141629 @default.

• next