FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108847838> ?p ?o ?g. }

• W2108847838 endingPage "1085" @default.
• W2108847838 startingPage "1075" @default.
• W2108847838 abstract "The role of hormone secretion and hormone clearance in the differential control of circulating levels of intact (I-) and carboxy-terminal (C-) immunoreactive parathyroid hormone (iPTH) was evaluated in 18 pentobarbital-anesthetized dogs. Catheters were installed in the aorta, left renal, and hepatic veins for sampling. Hepatic and renal blood flows were calculated from sulfobromophtalein (BSP) and p-aminohippuric acid (PAH) extraction and clearance. I- and C-iPTH were measured during a 1 h of infusion of CaCl2 or Na2EDTA. High-performance liquid chromatography (HPLC) profiles of I- and C-iPTH in and out of the liver and kidney were also obtained. Data on two dogs (one CaCl2 and one Na2EDTA infusion) were pooled for the analysis of one parathyroid function using a four-parameter mathematical model. Results obtained in the basal state and during analysis of the parathyroid function were also compared with those of 24 awakened dogs. Results are means ± SD. Anesthetized dogs had lower levels of Ca2+ (1.29 ± 0.03 vs. 1.34 ± 0.04 mmol/l; p < 0.001) and higher levels of I- (11.5 ± 5.7 vs. 3.0 ± 1.9 pmol/l, p < 0.001) and C-iPTH (52 ± 20.9 vs. 22.8 ± 10.5 pmol/l; p < 0.001) than awakened dogs. Their stimulated (S) and nonsuppressible (NS) I-iPTH levels were increased 2- and 4-fold, respectively, while similar C-iPTH levels rose only 1.35- and 1.75-fold; this caused their S (4.4 ± 0.7 vs. 6.8 ± 1.9; p < 0.001) and NS (24.6 ± 11.8 vs. 49.8 ± 27.5; p < 0.05) C-iPTH/I-iPTH ratios to decrease. This was not explained by different renal clearance rates of I- and C-iPTH since both were similar at ∼10 ml/kg/minute and unaffected by Ca2+ concentration. Clearance of all I- and C-iPTH HPLC molecular forms by the kidney appeared equal. A 50% decrease in the hepatic clearance of I-iPTH to ∼12 ml/kg/minute in pentobarbital-anesthetized dogs, related to a lower hepatic blood flow, explained the higher levels of S and NS I-iPTH in these animals. I-iPTH hepatic clearance was unaffected by Ca2+ concentration. C-iPTH hepatic clearance was much lower at ∼5 ml/kg/minute, abolished by hypercalcemia, and reduced by the influence of anesthesia on hepatic blood flow. This also explained the higher S C-iPTH levels in anesthetized animals. I-PTH(1–84) detected by the C-iPTH assay explained only 37.6% of the hepatic C-iPTH clearance in hypocalcemia and 73.3% in hypercalcemia. Overall, our results indicate that total C-iPTH clearance is about 40.2% that of I-iPTH in hypocalcemia and 41.3% in hypercalcemia. This would only explain a 2.4- to 2.5-fold difference in circulating levels of I- and C-iPTH if secretion rates were equal; the larger difference observed in S and NS C-iPTH/ I-iPTH ratio values is thus mainly explained by different production rates." @default.
• W2108847838 created "2016-06-24" @default.
• W2108847838 creator A5000007657 @default.
• W2108847838 creator A5003847350 @default.
• W2108847838 creator A5024888149 @default.
• W2108847838 creator A5034326980 @default.
• W2108847838 creator A5077151474 @default.
• W2108847838 date "2009-12-03" @default.
• W2108847838 modified "2023-10-17" @default.
• W2108847838 title "Influence of Ca2+ concentration on the clearance and circulating levels of intact and carboxy-terminal iPTH in pentobarbital-anesthetized dogs" @default.
• W2108847838 cites W1964081826 @default.
• W2108847838 cites W1967693032 @default.
• W2108847838 cites W1970121423 @default.
• W2108847838 cites W1977811131 @default.
• W2108847838 cites W1986068959 @default.
• W2108847838 cites W2002289535 @default.
• W2108847838 cites W2006611546 @default.
• W2108847838 cites W2013395805 @default.
• W2108847838 cites W2017994261 @default.
• W2108847838 cites W2021930642 @default.
• W2108847838 cites W2026062788 @default.
• W2108847838 cites W2027393714 @default.
• W2108847838 cites W2030683933 @default.
• W2108847838 cites W2041558196 @default.
• W2108847838 cites W2050550551 @default.
• W2108847838 cites W2053883384 @default.
• W2108847838 cites W2055156259 @default.
• W2108847838 cites W2055902299 @default.
• W2108847838 cites W2075310577 @default.
• W2108847838 cites W2075798303 @default.
• W2108847838 cites W2085004452 @default.
• W2108847838 cites W2105139565 @default.
• W2108847838 cites W2109175460 @default.
• W2108847838 cites W2112908425 @default.
• W2108847838 cites W2113376778 @default.
• W2108847838 cites W2124861503 @default.
• W2108847838 cites W2135178867 @default.
• W2108847838 cites W2153655978 @default.
• W2108847838 cites W2157625475 @default.
• W2108847838 cites W2165199263 @default.
• W2108847838 cites W2165609330 @default.
• W2108847838 cites W2338457994 @default.
• W2108847838 cites W2399505227 @default.
• W2108847838 doi "https://doi.org/10.1002/jbmr.5650110806" @default.
• W2108847838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8854243" @default.
• W2108847838 hasPublicationYear "2009" @default.
• W2108847838 type Work @default.
• W2108847838 sameAs 2108847838 @default.
• W2108847838 citedByCount "16" @default.
• W2108847838 countsByYear W21088478382014 @default.
• W2108847838 crossrefType "journal-article" @default.
• W2108847838 hasAuthorship W2108847838A5000007657 @default.
• W2108847838 hasAuthorship W2108847838A5003847350 @default.
• W2108847838 hasAuthorship W2108847838A5024888149 @default.
• W2108847838 hasAuthorship W2108847838A5034326980 @default.
• W2108847838 hasAuthorship W2108847838A5077151474 @default.
• W2108847838 hasConcept C126322002 @default.
• W2108847838 hasConcept C134018914 @default.
• W2108847838 hasConcept C142225936 @default.
• W2108847838 hasConcept C159641895 @default.
• W2108847838 hasConcept C185592680 @default.
• W2108847838 hasConcept C2776755955 @default.
• W2108847838 hasConcept C2780091579 @default.
• W2108847838 hasConcept C2781208988 @default.
• W2108847838 hasConcept C519063684 @default.
• W2108847838 hasConcept C71924100 @default.
• W2108847838 hasConceptScore W2108847838C126322002 @default.
• W2108847838 hasConceptScore W2108847838C134018914 @default.
• W2108847838 hasConceptScore W2108847838C142225936 @default.
• W2108847838 hasConceptScore W2108847838C159641895 @default.
• W2108847838 hasConceptScore W2108847838C185592680 @default.
• W2108847838 hasConceptScore W2108847838C2776755955 @default.
• W2108847838 hasConceptScore W2108847838C2780091579 @default.
• W2108847838 hasConceptScore W2108847838C2781208988 @default.
• W2108847838 hasConceptScore W2108847838C519063684 @default.
• W2108847838 hasConceptScore W2108847838C71924100 @default.
• W2108847838 hasIssue "8" @default.
• W2108847838 hasLocation W21088478381 @default.
• W2108847838 hasLocation W21088478382 @default.
• W2108847838 hasOpenAccess W2108847838 @default.
• W2108847838 hasPrimaryLocation W21088478381 @default.
• W2108847838 hasRelatedWork W1970114012 @default.
• W2108847838 hasRelatedWork W2020170405 @default.
• W2108847838 hasRelatedWork W2048039626 @default.
• W2108847838 hasRelatedWork W2092271911 @default.
• W2108847838 hasRelatedWork W2117914587 @default.
• W2108847838 hasRelatedWork W2161282407 @default.
• W2108847838 hasRelatedWork W2162385374 @default.
• W2108847838 hasRelatedWork W2284042012 @default.
• W2108847838 hasRelatedWork W2404152533 @default.
• W2108847838 hasRelatedWork W2748952813 @default.
• W2108847838 hasVolume "11" @default.
• W2108847838 isParatext "false" @default.
• W2108847838 isRetracted "false" @default.
• W2108847838 magId "2108847838" @default.
• W2108847838 workType "article" @default.