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- W2108865569 abstract "We have investigated the expression of transforming growth factor (TGF)-β1,-β2, and -β3 in developing, degenerating, and regenerating rat peripheral nerve by immunohistochemistry and Northern blot analysis. In normal adult sciatic nerve, TGF-β1, -β2, and -β3 are detected in the cytoplasm of Schwann cells, and the levels of TGF-β1 and -β3 mRNAs are constant during post-natal development. When sciatic nerves are transected to cause axonal degeneration and prevent axonal regeneration, the level of TGF-β1 mRNA in the distal nerve-stump increases markedly and remains elevated, whereas the level of TGF-β3 mRNA falls modestly and remains depressed. When sciatic nerves are crushed to cause axonal degeneration and allow axonal regeneration, the level of TGF-β1 mRNA initially increases as axons degenerate, and then falls as axons regenerate. TGF-β2 mRNA was not detected in developing or lesioned sciatic nerves at any time. Cultured Schwann cells have high levels of TGF-β1 mRNA, the amount of which is reduced by forskolin, which mimicks the effect of axonal contact. These data demonstrate that Schwann cells express TGF-β1, -β2, and -β3, and that TGF-β1 and -β3 mRNA predominate over TGF-β2 mRNA in peripheral nerve. Axonal contact and forskolin decrease the expression of TGF-β1 in Schwann cells. © 1993 Wiley-Liss, Inc." @default.
- W2108865569 created "2016-06-24" @default.
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- W2108865569 date "1993-01-01" @default.
- W2108865569 modified "2023-09-25" @default.
- W2108865569 title "Axons modulate the expression of transforming growth factor-betas in Schwann cells" @default.
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- W2108865569 doi "https://doi.org/10.1002/glia.440080407" @default.
- W2108865569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8406683" @default.
- W2108865569 hasPublicationYear "1993" @default.
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