FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108889347> ?p ?o ?g. }

• W2108889347 endingPage "1660" @default.
• W2108889347 startingPage "1655" @default.
• W2108889347 abstract "Adverse left ventricular (LV) remodeling after myocardial infarction (MI) is a major cause for heart failure. Molecular modifiers of the remodeling process remain poorly defined. Patients with heart failure after MI have reduced LV expression levels of muscle LIM protein (MLP), a component of the sarcomeric Z-disk that is involved in the integration of stress signals in cardiomyocytes. By using heterozygous MLP mutant (MLP+/-) mice, we explored the role of MLP in post-MI remodeling. LV dimensions and function were similar in sham-operated WT and MLP+/- mice. After MI, however, MLP+/- mice displayed more pronounced LV dilatation and systolic dysfunction and decreased survival compared with WT mice, indicating that reduced MLP levels predispose to adverse LV remodeling. LV dilatation in MLP+/- mice was associated with reduced thickening but enhanced elongation of cardiomyocytes. Activation of the stress-responsive, prohypertrophic calcineurin-nuclear factor of activated T-cells (NFAT) signaling pathway was reduced in MLP+/- mice after MI, as shown by a blunted transcriptional activation of NFAT in cardiomyocytes isolated from MLP+/-/NFAT-luciferase reporter gene transgenic mice. Calcineurin was colocalized with MLP at the Z-disk in WT mice but was displaced from the Z-disk in MLP+/- mice, indicating that MLP is essential for calcineurin anchorage to the Z-disk. In vitro assays in cardiomyocytes with down-regulated MLP confirmed that MLP is required for stress-induced calcineurin-NFAT activation. Our study reveals a link between the stress sensor MLP and the calcineurin-NFAT pathway at the sarcomeric Z-disk in cardiomyocytes and indicates that reduced MLP-calcineurin signaling predisposes to adverse remodeling after MI." @default.
• W2108889347 created "2016-06-24" @default.
• W2108889347 creator A5009727982 @default.
• W2108889347 creator A5015024142 @default.
• W2108889347 creator A5015404078 @default.
• W2108889347 creator A5020999757 @default.
• W2108889347 creator A5038620753 @default.
• W2108889347 creator A5053529402 @default.
• W2108889347 creator A5053855722 @default.
• W2108889347 creator A5056466365 @default.
• W2108889347 creator A5063430611 @default.
• W2108889347 creator A5066349732 @default.
• W2108889347 creator A5075550603 @default.
• W2108889347 creator A5075851805 @default.
• W2108889347 creator A5086772399 @default.
• W2108889347 creator A5091719513 @default.
• W2108889347 date "2005-01-21" @default.
• W2108889347 modified "2023-09-27" @default.
• W2108889347 title "Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc" @default.
• W2108889347 cites W1486435880 @default.
• W2108889347 cites W1492344672 @default.
• W2108889347 cites W1825664270 @default.
• W2108889347 cites W1966485417 @default.
• W2108889347 cites W1977316721 @default.
• W2108889347 cites W1978775253 @default.
• W2108889347 cites W1984240649 @default.
• W2108889347 cites W1985255815 @default.
• W2108889347 cites W1988710835 @default.
• W2108889347 cites W2023097850 @default.
• W2108889347 cites W2023988777 @default.
• W2108889347 cites W2036754849 @default.
• W2108889347 cites W2041611268 @default.
• W2108889347 cites W2047503478 @default.
• W2108889347 cites W2050839858 @default.
• W2108889347 cites W2052780003 @default.
• W2108889347 cites W2052863274 @default.
• W2108889347 cites W2053870616 @default.
• W2108889347 cites W2059102370 @default.
• W2108889347 cites W2060072866 @default.
• W2108889347 cites W2066243964 @default.
• W2108889347 cites W2068671266 @default.
• W2108889347 cites W2079509424 @default.
• W2108889347 cites W2084347012 @default.
• W2108889347 cites W2085933444 @default.
• W2108889347 cites W2091383902 @default.
• W2108889347 cites W2101667426 @default.
• W2108889347 cites W2103822936 @default.
• W2108889347 cites W2116717165 @default.
• W2108889347 cites W2122074209 @default.
• W2108889347 cites W2136365576 @default.
• W2108889347 cites W2138237143 @default.
• W2108889347 cites W2147490295 @default.
• W2108889347 cites W2152603999 @default.
• W2108889347 cites W2153430526 @default.
• W2108889347 cites W2156433522 @default.
• W2108889347 cites W2156920534 @default.
• W2108889347 cites W2158101938 @default.
• W2108889347 cites W2168898453 @default.
• W2108889347 cites W2178127997 @default.
• W2108889347 cites W4247399026 @default.
• W2108889347 doi "https://doi.org/10.1073/pnas.0405488102" @default.
• W2108889347 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/547821" @default.
• W2108889347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15665106" @default.
• W2108889347 hasPublicationYear "2005" @default.
• W2108889347 type Work @default.
• W2108889347 sameAs 2108889347 @default.
• W2108889347 citedByCount "146" @default.
• W2108889347 countsByYear W21088893472012 @default.
• W2108889347 countsByYear W21088893472013 @default.
• W2108889347 countsByYear W21088893472014 @default.
• W2108889347 countsByYear W21088893472015 @default.
• W2108889347 countsByYear W21088893472016 @default.
• W2108889347 countsByYear W21088893472017 @default.
• W2108889347 countsByYear W21088893472018 @default.
• W2108889347 countsByYear W21088893472019 @default.
• W2108889347 countsByYear W21088893472020 @default.
• W2108889347 countsByYear W21088893472021 @default.
• W2108889347 countsByYear W21088893472022 @default.
• W2108889347 countsByYear W21088893472023 @default.
• W2108889347 crossrefType "journal-article" @default.
• W2108889347 hasAuthorship W2108889347A5009727982 @default.
• W2108889347 hasAuthorship W2108889347A5015024142 @default.
• W2108889347 hasAuthorship W2108889347A5015404078 @default.
• W2108889347 hasAuthorship W2108889347A5020999757 @default.
• W2108889347 hasAuthorship W2108889347A5038620753 @default.
• W2108889347 hasAuthorship W2108889347A5053529402 @default.
• W2108889347 hasAuthorship W2108889347A5053855722 @default.
• W2108889347 hasAuthorship W2108889347A5056466365 @default.
• W2108889347 hasAuthorship W2108889347A5063430611 @default.
• W2108889347 hasAuthorship W2108889347A5066349732 @default.
• W2108889347 hasAuthorship W2108889347A5075550603 @default.
• W2108889347 hasAuthorship W2108889347A5075851805 @default.
• W2108889347 hasAuthorship W2108889347A5086772399 @default.
• W2108889347 hasAuthorship W2108889347A5091719513 @default.
• W2108889347 hasBestOaLocation W21088893471 @default.
• W2108889347 hasConcept C126322002 @default.
• W2108889347 hasConcept C128057223 @default.
• W2108889347 hasConcept C134018914 @default.

• next