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• W2108897579 abstract "Tetra-tert-butyl zinc(II) phthalocyanine has attracted great attention as an effective photosensitizer in the field of photodynamic therapy. However, tetra-tert-butyl zinc(II) phthalocyanine is hydrophobic and trends to aggregate to form the inactive congeries in aqueous solution, which dramatically reduce its photodynamic activity. To solve this problem, tetra- tert-butyl zinc(II) phthalocyanine was encapsulated into silica nanoparticles using microemulsion method and its properties were studied using spectroscopic methods. After embedded inside the silica nanoparticles, the water-solubility, stability and monomer percent of phthalocyanine in water were greatly improved comparing with the free phthalocyanines, and therefore, its photo-induced singlet oxygen generation efficacy of drug-doped silica nanoparticles was improved. The results indicated that encapsulation hydrophobic phthalocyanine into silica nanoparticles was an effective way to solve their problems and promote their clinical application." @default.
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• W2108897579 date "2011-01-01" @default.
• W2108897579 modified "2023-09-27" @default.
• W2108897579 title "Property study of a new silica nanoparticle delivery system of hydrophobic phthalocyanine using spectroscopic method" @default.
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• W2108897579 doi "https://doi.org/10.3233/spe-2011-0536" @default.
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