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- W2108899999 abstract "Visual function in humans degrades during the early stage of senescence beginning from middle 50s to 60s. To identify its underlying neural mechanisms, we investigated the aging effects on the primary visual cortex (V1) cells in early senescent (ES) monkeys (Macaca mulatta). Under anesthesia, receptive field properties of V1 cells were examined by extracellular single-unit recordings in the young adult (YA; 5-6 years old), ES (19-24 years old), and late senescent (LS; 28-32 years old) monkeys. We found clear indications of functional degradation in early senescence, including impaired stimulus selectivities, increased level of spontaneous activity and declined signal-to-noise ratio, and dynamic range of V1 cell responses. Importantly, the functional degradation in early senescence exhibited unique features that were different from the results for the LS animals, such as remarkable individual variability in orientation selectivity and unchanged peak response elicited by visual stimulation. Our results demonstrate that the function of V1 degrades during the early stage of aging in nonhuman primate, suggesting potential neural correlates for functional deficits observed in early senescence in human subjects. Moreover, these results provide new insight into the dynamics of the aging-related functional deterioration, revealing a more complex and heterogeneous picture of this process." @default.
- W2108899999 created "2016-06-24" @default.
- W2108899999 creator A5043637911 @default.
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- W2108899999 creator A5078640168 @default.
- W2108899999 creator A5084741637 @default.
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- W2108899999 date "2012-08-31" @default.
- W2108899999 modified "2023-10-05" @default.
- W2108899999 title "Functional Degradation of the Primary Visual Cortex During Early Senescence in Rhesus Monkeys" @default.
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- W2108899999 cites W1806149873 @default.
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- W2108899999 cites W1966688969 @default.
- W2108899999 cites W1970359645 @default.
- W2108899999 cites W1973230208 @default.
- W2108899999 cites W1975694860 @default.
- W2108899999 cites W1977867534 @default.
- W2108899999 cites W1980326471 @default.
- W2108899999 cites W1982464537 @default.
- W2108899999 cites W1991535090 @default.
- W2108899999 cites W1991661185 @default.
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- W2108899999 cites W1998288553 @default.
- W2108899999 cites W2000701685 @default.
- W2108899999 cites W2017108196 @default.
- W2108899999 cites W2023063954 @default.
- W2108899999 cites W2025995788 @default.
- W2108899999 cites W2026132386 @default.
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- W2108899999 cites W2035046759 @default.
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- W2108899999 cites W2067822845 @default.
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- W2108899999 cites W2072652550 @default.
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- W2108899999 cites W2079755276 @default.
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- W2108899999 cites W2168375193 @default.
- W2108899999 cites W2168467995 @default.
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- W2108899999 doi "https://doi.org/10.1093/cercor/bhs282" @default.
- W2108899999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22941715" @default.
- W2108899999 hasPublicationYear "2012" @default.
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