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• W2108902489 startingPage "179" @default.
• W2108902489 abstract "<h3>Hypothesis</h3> To investigate the impact of total thyroidectomy on the rate of completion thyroidectomy for incidentally found thyroid cancer in euthyroid multinodular goiter. <h3>Design</h3> A randomized, prospective clinical trial. <h3>Setting</h3> A tertiary referral center. <h3>Patients</h3> Patients with euthyroid multinodular goiter without any preoperative suspicion of malignancy, history of familial thyroid cancer, or previous exposure to radiation were randomized (according to a random table) to total or near-total thyroidectomy leaving no remnant tissue or less than 1 g (group 1; n = 109) or bilateral subtotal thyroidectomy leaving 5 g or more of remnant tissue (group 2; n = 109). Patients with preoperative or perioperative suspicion of malignancy were excluded. <h3>Main Outcome Measures</h3> We compared the complication rates and the incidence of thyroid cancer requiring radioactive iodine ablation and completion thyroidectomy between groups. <h3>Results</h3> There were no permanent complications. The rates of temporary unilateral vocal cord dysfunction and hypoparathyroidism showed no significant difference between groups 1 and 2 (0.9% vs 0.9% and 1.8% vs 0.9%, respectively;<i>P</i>>.05). Papillary cancer was found in 10 group 1 patients (9.2%) and 8 group 2 patients (7.3%) (<i>P</i>= .80). Of the 9 patients requiring radioactive iodine ablation, reoperation was avoided in 5 group 1 patients; the remaining 4 group 2 patients underwent completion thyroidectomy (<i>P</i>= .007). <h3>Conclusion</h3> We recommend total or near-total thyroidectomy in multinodular goiter to eliminate the necessity for early completion thyroidectomy in case of a final diagnosis of thyroid cancer." @default.
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• W2108902489 date "2004-02-01" @default.
• W2108902489 modified "2023-10-17" @default.
• W2108902489 title "The Advantage of Total Thyroidectomy to Avoid Reoperation for Incidental Thyroid Cancer in Multinodular Goiter" @default.
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• W2108902489 doi "https://doi.org/10.1001/archsurg.139.2.179" @default.
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