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- W2108907566 abstract "The chemical composition of the essential oil of Nepeta govaniana was determined by GC-FID with relative abundance and relative retention indices (RRI). The GC-FID analysis led to identification of ten compounds accounting for 86.02% of total oil composition. The dominant compounds present were 1, 2, 3, 6-tetramethylbicyclo [2, 2, 2] octa-2, 5-diene (32.35%) followed by geijerene (20.65%) and pregeijerene (6.18%). The oil was screened for cytotoxic activity against a panel of five cancer cell lines viz lung (A-549), breast (MCF-7), pancreas (MiaPaCa-2) and Colon (HCT-116 and Colo-205) using sulforhodamine B assay (SRB). The Nepeta govaniana essential oil exhibited a concentration-dependent as well as cell line-dependent growth inhibition of cancer cells and was found to be most active against the lung (A-549; IC50 of 19.1 ± 0.9 µg/ml) followed by colon (colo-205; IC50 of 21.3±1.1 µg/ml) cancer cell lines." @default.
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- W2108907566 date "2014-06-01" @default.
- W2108907566 modified "2023-09-26" @default.
- W2108907566 title "Cytotoxic activity and GC-MS analysis of the constituents of essential oil of Nepeta govaniana (Wall. ex Benth) from Jammu and Kashmir, India." @default.
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