FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108909957> ?p ?o ?g. }

• W2108909957 endingPage "1114" @default.
• W2108909957 startingPage "1105" @default.
• W2108909957 abstract "These studies tested whether antigenic competition between T cells occurs. We generated CD8(+) T cell responses in H-2(b) mice against the dominant ovalbumin epitope SIINFEKL (ova8) and subdominant epitope KRVVFDKL, using either vaccinia virus expressing ovalbumin (VV-ova) or peptide-pulsed dendritic cells. CD8(+) T cell responses were visualized by major histocompatibility complex class I-peptide tetrameric molecules. Transfer of transgenic T cells with high affinity for ova8 (OT1 T cells) completely inhibited the response of host antigen-specific T cells to either antigen, demonstrating that T cells can directly compete with each other for response to antigen. OT1 cells also inhibited CD8(+) T cell responses to an unrelated peptide, SIYRYGGL, providing it was presented on the same dendritic cells as ova8. These inhibitions were not due to a more rapid clearance of virus or antigen-presenting cells (APCs) by the OT1 cells. Rather, the inhibition was caused by competition for antigen and antigen-bearing cells, since it could be overcome by the injection of large numbers of antigen-pulsed dendritic cells. These results imply that common properties of T cell responses, such as epitope dominance and secondary response affinity maturation, are the result of competitive interactions between antigen-bearing APC and T cell subsets." @default.
• W2108909957 created "2016-06-24" @default.
• W2108909957 creator A5004362492 @default.
• W2108909957 creator A5031485012 @default.
• W2108909957 creator A5031718088 @default.
• W2108909957 creator A5040853234 @default.
• W2108909957 creator A5044329784 @default.
• W2108909957 creator A5045845014 @default.
• W2108909957 creator A5066347052 @default.
• W2108909957 date "2000-10-09" @default.
• W2108909957 modified "2023-09-25" @default.
• W2108909957 title "T Cells Compete for Access to Antigen-Bearing Antigen-Presenting Cells" @default.
• W2108909957 cites W1481440696 @default.
• W2108909957 cites W1596782482 @default.
• W2108909957 cites W1671510944 @default.
• W2108909957 cites W1781159025 @default.
• W2108909957 cites W1849458823 @default.
• W2108909957 cites W1959677146 @default.
• W2108909957 cites W1978150150 @default.
• W2108909957 cites W1995925083 @default.
• W2108909957 cites W1996483176 @default.
• W2108909957 cites W1999995106 @default.
• W2108909957 cites W2001656273 @default.
• W2108909957 cites W2003238220 @default.
• W2108909957 cites W2010436799 @default.
• W2108909957 cites W2031263707 @default.
• W2108909957 cites W2031962663 @default.
• W2108909957 cites W2033374207 @default.
• W2108909957 cites W2039848934 @default.
• W2108909957 cites W2043759777 @default.
• W2108909957 cites W2050960915 @default.
• W2108909957 cites W2058634008 @default.
• W2108909957 cites W2063711348 @default.
• W2108909957 cites W2070530924 @default.
• W2108909957 cites W2072318191 @default.
• W2108909957 cites W2076072838 @default.
• W2108909957 cites W2076121010 @default.
• W2108909957 cites W2105568177 @default.
• W2108909957 cites W2108744965 @default.
• W2108909957 cites W2113747885 @default.
• W2108909957 cites W2149366474 @default.
• W2108909957 cites W2163351493 @default.
• W2108909957 cites W2175227354 @default.
• W2108909957 cites W2317493325 @default.
• W2108909957 cites W2335732256 @default.
• W2108909957 cites W4240510096 @default.
• W2108909957 cites W4248168278 @default.
• W2108909957 cites W4313347679 @default.
• W2108909957 doi "https://doi.org/10.1084/jem.192.8.1105" @default.
• W2108909957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2195874" @default.
• W2108909957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11034600" @default.
• W2108909957 hasPublicationYear "2000" @default.
• W2108909957 type Work @default.
• W2108909957 sameAs 2108909957 @default.
• W2108909957 citedByCount "408" @default.
• W2108909957 countsByYear W21089099572012 @default.
• W2108909957 countsByYear W21089099572013 @default.
• W2108909957 countsByYear W21089099572014 @default.
• W2108909957 countsByYear W21089099572015 @default.
• W2108909957 countsByYear W21089099572016 @default.
• W2108909957 countsByYear W21089099572017 @default.
• W2108909957 countsByYear W21089099572018 @default.
• W2108909957 countsByYear W21089099572019 @default.
• W2108909957 countsByYear W21089099572020 @default.
• W2108909957 countsByYear W21089099572021 @default.
• W2108909957 countsByYear W21089099572022 @default.
• W2108909957 countsByYear W21089099572023 @default.
• W2108909957 crossrefType "journal-article" @default.
• W2108909957 hasAuthorship W2108909957A5004362492 @default.
• W2108909957 hasAuthorship W2108909957A5031485012 @default.
• W2108909957 hasAuthorship W2108909957A5031718088 @default.
• W2108909957 hasAuthorship W2108909957A5040853234 @default.
• W2108909957 hasAuthorship W2108909957A5044329784 @default.
• W2108909957 hasAuthorship W2108909957A5045845014 @default.
• W2108909957 hasAuthorship W2108909957A5066347052 @default.
• W2108909957 hasBestOaLocation W21089099571 @default.
• W2108909957 hasConcept C147483822 @default.
• W2108909957 hasConcept C153911025 @default.
• W2108909957 hasConcept C154317977 @default.
• W2108909957 hasConcept C195616568 @default.
• W2108909957 hasConcept C202751555 @default.
• W2108909957 hasConcept C203014093 @default.
• W2108909957 hasConcept C207936829 @default.
• W2108909957 hasConcept C2776090121 @default.
• W2108909957 hasConcept C39347974 @default.
• W2108909957 hasConcept C55493867 @default.
• W2108909957 hasConcept C67662055 @default.
• W2108909957 hasConcept C83464605 @default.
• W2108909957 hasConcept C86803240 @default.
• W2108909957 hasConcept C8840205 @default.
• W2108909957 hasConcept C8891405 @default.
• W2108909957 hasConcept C95444343 @default.
• W2108909957 hasConceptScore W2108909957C147483822 @default.
• W2108909957 hasConceptScore W2108909957C153911025 @default.
• W2108909957 hasConceptScore W2108909957C154317977 @default.
• W2108909957 hasConceptScore W2108909957C195616568 @default.
• W2108909957 hasConceptScore W2108909957C202751555 @default.
• W2108909957 hasConceptScore W2108909957C203014093 @default.

• next