FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108917325> ?p ?o ?g. }

• W2108917325 endingPage "525" @default.
• W2108917325 startingPage "519" @default.
• W2108917325 abstract "Oxysterols are oxygenated derivatives of cholesterol that may be formed endogenously or absorbed from the diet. Significant amounts of oxysterols have frequently been identified in foods of animal origin, in particular highly processed foods. To date, oxysterols have been shown to possess diverse biological activities; however, recent attention has focused on their potential role in the development of atherosclerosis. Oxysterols have been reported to induce apoptosis in cells of the arterial wall, a primary process in the development of atheroma. The aim of the present study was to identify the role of the mitochondria in the apoptotic pathways induced by the oxysterols 7β-hydroxycholesterol (7β-OH) and cholesterol-5β,6β-epoxide (β-epoxide) in U937 cells. To this end, we investigated the effects of these oxysterols on mitochondrial membrane potential, caspase-8 activity, the mitochondrial permeability transition pore and cytochrome c release. 7β-OH-induced apoptosis was associated with a loss in mitochondrial membrane potential after 2 h, accompanied by cytochrome c release from the mitochondria into the cytosol after 16 h. Pre-treatment with a range of inhibitors of the mitochondrial permeability transition pore protected against 7β-OH-induced cell death. In contrast, β-epoxide induced a slight increase in caspase-8 activity but had no effect on mitochondrial membrane potential or cytochrome c release. The present results confirm that 7β-OH-induced apoptosis occurs via the mitochondrial pathway and highlights differences in the apoptotic pathways induced by 7β-OH and β-epoxide in U937 cells." @default.
• W2108917325 created "2016-06-24" @default.
• W2108917325 creator A5000929859 @default.
• W2108917325 creator A5058132015 @default.
• W2108917325 creator A5074266219 @default.
• W2108917325 date "2005-10-01" @default.
• W2108917325 modified "2023-10-18" @default.
• W2108917325 title "The role of the mitochondria in apoptosis induced by 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide" @default.
• W2108917325 cites W1265747563 @default.
• W2108917325 cites W1502903705 @default.
• W2108917325 cites W1862564406 @default.
• W2108917325 cites W1964599275 @default.
• W2108917325 cites W1968112618 @default.
• W2108917325 cites W1972733192 @default.
• W2108917325 cites W1973995316 @default.
• W2108917325 cites W1975370063 @default.
• W2108917325 cites W1978442615 @default.
• W2108917325 cites W1987502752 @default.
• W2108917325 cites W1990544060 @default.
• W2108917325 cites W1993720376 @default.
• W2108917325 cites W1998403790 @default.
• W2108917325 cites W2008374272 @default.
• W2108917325 cites W2008422990 @default.
• W2108917325 cites W2010147013 @default.
• W2108917325 cites W2015863843 @default.
• W2108917325 cites W2026072968 @default.
• W2108917325 cites W2026213230 @default.
• W2108917325 cites W2036193061 @default.
• W2108917325 cites W2039682492 @default.
• W2108917325 cites W2040105292 @default.
• W2108917325 cites W2042252937 @default.
• W2108917325 cites W2042584010 @default.
• W2108917325 cites W2054295214 @default.
• W2108917325 cites W2056141575 @default.
• W2108917325 cites W2057002702 @default.
• W2108917325 cites W2073398280 @default.
• W2108917325 cites W2077007534 @default.
• W2108917325 cites W2079763440 @default.
• W2108917325 cites W2080963939 @default.
• W2108917325 cites W2081176045 @default.
• W2108917325 cites W2086918192 @default.
• W2108917325 cites W2091083766 @default.
• W2108917325 cites W2102870521 @default.
• W2108917325 cites W2117850338 @default.
• W2108917325 cites W2138146904 @default.
• W2108917325 cites W2170347547 @default.
• W2108917325 cites W2439249793 @default.
• W2108917325 cites W4232534952 @default.
• W2108917325 doi "https://doi.org/10.1079/bjn20051524" @default.
• W2108917325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16197575" @default.
• W2108917325 hasPublicationYear "2005" @default.
• W2108917325 type Work @default.
• W2108917325 sameAs 2108917325 @default.
• W2108917325 citedByCount "51" @default.
• W2108917325 countsByYear W21089173252012 @default.
• W2108917325 countsByYear W21089173252013 @default.
• W2108917325 countsByYear W21089173252014 @default.
• W2108917325 countsByYear W21089173252016 @default.
• W2108917325 countsByYear W21089173252017 @default.
• W2108917325 countsByYear W21089173252018 @default.
• W2108917325 countsByYear W21089173252019 @default.
• W2108917325 countsByYear W21089173252020 @default.
• W2108917325 countsByYear W21089173252021 @default.
• W2108917325 countsByYear W21089173252023 @default.
• W2108917325 crossrefType "journal-article" @default.
• W2108917325 hasAuthorship W2108917325A5000929859 @default.
• W2108917325 hasAuthorship W2108917325A5058132015 @default.
• W2108917325 hasAuthorship W2108917325A5074266219 @default.
• W2108917325 hasBestOaLocation W21089173251 @default.
• W2108917325 hasConcept C108634530 @default.
• W2108917325 hasConcept C13591479 @default.
• W2108917325 hasConcept C181199279 @default.
• W2108917325 hasConcept C181911157 @default.
• W2108917325 hasConcept C185592680 @default.
• W2108917325 hasConcept C190283241 @default.
• W2108917325 hasConcept C193349765 @default.
• W2108917325 hasConcept C2778163477 @default.
• W2108917325 hasConcept C28859421 @default.
• W2108917325 hasConcept C29311851 @default.
• W2108917325 hasConcept C31573885 @default.
• W2108917325 hasConcept C55493867 @default.
• W2108917325 hasConcept C86803240 @default.
• W2108917325 hasConcept C95444343 @default.
• W2108917325 hasConcept C98424977 @default.
• W2108917325 hasConcept C98539663 @default.
• W2108917325 hasConceptScore W2108917325C108634530 @default.
• W2108917325 hasConceptScore W2108917325C13591479 @default.
• W2108917325 hasConceptScore W2108917325C181199279 @default.
• W2108917325 hasConceptScore W2108917325C181911157 @default.
• W2108917325 hasConceptScore W2108917325C185592680 @default.
• W2108917325 hasConceptScore W2108917325C190283241 @default.
• W2108917325 hasConceptScore W2108917325C193349765 @default.
• W2108917325 hasConceptScore W2108917325C2778163477 @default.
• W2108917325 hasConceptScore W2108917325C28859421 @default.
• W2108917325 hasConceptScore W2108917325C29311851 @default.
• W2108917325 hasConceptScore W2108917325C31573885 @default.
• W2108917325 hasConceptScore W2108917325C55493867 @default.
• W2108917325 hasConceptScore W2108917325C86803240 @default.

• next